U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FIP1 cleavage polyadenylation factor subunit FIP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853555, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FIP1
    Official Full Name
    cleavage polyadenylation factor subunit FIP1
    Primary source
    SGD:S000003853
    Locus tag
    YJR093C
    See related
    AllianceGenome:SGD:S000003853; FungiDB:YJR093C; VEuPathDB:YJR093C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Contributes to RNA binding activity. Involved in mRNA processing. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human FIP1L1 (factor interacting with PAPOLA and CPSF1). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FIP1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (603220..604203, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Jsn1p Neighboring gene Bud4p Neighboring gene transcription factor IME1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase. Preker PJ, et al. Cell, 1995 May 5. PMID 7736590
    2. Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein. Meinke G, et al. Biochemistry, 2008 Jul 1. PMID 18537269, Free PMC Article
    3. Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor. Tacahashi Y, et al. Nucleic Acids Res, 2003 Mar 15. PMID 12626716, Free PMC Article
    4. Fip1 regulates the activity of Poly(A) polymerase through multiple interactions. Helmling S, et al. Mol Cell Biol, 2001 Mar. PMID 11238938, Free PMC Article
    5. Processivity of the Saccharomyces cerevisiae poly(A) polymerase requires interactions at the carboxyl-terminal RNA binding domain. Zhelkovsky A, et al. Mol Cell Biol, 1998 Oct. PMID 9742111, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results indicate that the Fip1 linker, through its flexibility and protein/protein interactions, allows Pap1 to reach the 3' end of the cleaved RNA and efficiently initiate poly(A) addition.
      Title: A flexible linker region in Fip1 is needed for efficient mRNA polyadenylation.
    2. in the absence of Pap1, Fip1 is largely, if not completely, unfolded
      Title: Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein.
    3. Data elucidate the role of Fip1 in the mRNA 3'-OH polyadenylation process.
      Title: Fip1--an essential component of the Saccharomyces cerevisiae polyadenylation machinery is phosophorylated by protein kinase CK2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cleavage polyadenylation factor subunit FIP1
    NP_012626.1
    • Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      603220..604203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181750.1 → NP_012626.1  TPA: cleavage polyadenylation factor subunit FIP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR1, P45976
      UniProtKB/TrEMBL
      A6ZQ48, B5VLP1, C7GMB4, G2WH95, N1P8T4
      Conserved Domains (1) summary
      COG5213
      Location:8 → 301
      FIP1; Polyadenylation factor I complex, subunit FIP1 [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45976.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools