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    PKP2 protein kinase PKP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852821, updated on 14-Nov-2024

    Summary

    Official Symbol
    PKP2
    Official Full Name
    protein kinase PKP2
    Primary source
    SGD:S000003027
    Locus tag
    YGL059W
    See related
    AllianceGenome:SGD:S000003027; FungiDB:YGL059W; VEuPathDB:YGL059W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in regulation of mitophagy. Located in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6 and branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to several human genes including BCKDK (branched chain keto acid dehydrogenase kinase); PDK1 (pyruvate dehydrogenase kinase 1); and PDK3 (pyruvate dehydrogenase kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See PKP2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (392223..393698)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Duo1p Neighboring gene Ybp2p Neighboring gene E2 ubiquitin-conjugating protein RAD6 Neighboring gene Gep7p

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein kinase PKP2
    NP_011456.5
    • Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      392223..393698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180924.4NP_011456.5  TPA: protein kinase PKP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011456.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU82, P53170
      UniProtKB/TrEMBL
      A6ZUB7, B3LHC8, B5VIR5, C7GRJ5, C8Z8I8, G2WE37, N1P5H8
      Conserved Domains (2) summary
      cd16929
      Location:248477
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
      pfam10436
      Location:79239
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase