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    CG5757 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5757provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034299
    Locus tag
    Dmel_CG5757
    See related
    AllianceGenome:FB:FBgn0034299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5757
    Summary
    Predicted to enable UMP/dUMP kinase activity; nucleoside diphosphate kinase activity; and thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion and nucleus. Is expressed in organism. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5757 in Genome Data Viewer
    Location:
    55B4-55B4; 2-84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18093723..18094900, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13981228..13982405, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45314 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45022 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis. McMillan EA, et al. J Biol Chem, 2018 Feb 23. PMID 29326167, Free PMC Article
    2. Transcriptional Correlates of Chronic Alcohol Neuroadaptation in Drosophila Larvae. Anqueira-González A, et al. Front Behav Neurosci, 2021. PMID 34803626, Free PMC Article
    3. A map of directional genetic interactions in a metazoan cell. Fischer B, et al. Elife, 2015 Mar 6. PMID 25748138, Free PMC Article
    4. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Pennemann FL, et al. Nat Commun, 2021 Dec 1. PMID 34853303, Free PMC Article
    5. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UMP/dUMP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dTDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTDP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTDP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dTTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTTP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dUDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUDP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5757-PA
    CG5757-PB
    NP_001261065.1
    NP_611290.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18093723..18094900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274136.1 → NP_001261065.1  uncharacterized protein Dmel_CG5757, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AP31, A1ZB29
      Conserved Domains (2) summary
      PLN02924
      Location:1 → 197
      PLN02924; thymidylate kinase
      pfam02223
      Location:12 → 191
      Thymidylate_kin; Thymidylate kinase

    2. NM_137446.4 → NP_611290.3  uncharacterized protein Dmel_CG5757, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611290.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AP31, A1ZB29
      Related
      FBpp0085966
      Conserved Domains (2) summary
      PLN02924
      Location:1 → 197
      PLN02924; thymidylate kinase
      pfam02223
      Location:12 → 191
      Thymidylate_kin; Thymidylate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZB29 A1ZB29
    Q7K2J3 Q7K2J3
    Q8SZQ0 Q8SZQ0

    Gene LinkOut

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