RPA2 Replication protein A2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RPA2provided by FlyBase
Official Full Name: Replication protein A2provided by FlyBase
Primary source: FLYBASE:FBgn0288834
Locus tag: Dmel_CG9273
See related: AllianceGenome:FB:FBgn0288834
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 153194_at; CG9273; D-SSB; Dmel\CG9273; DmRP-A; DmRPA; dRP-A; DRP-A; dRPA2; RP-A; RPA; RPA 30 kDa; RpA-30; RpA2; RPA30; Ssb-30
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA recombination; DNA repair; and DNA replication. Predicted to be located in nucleus. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 38F6-38F6; 2-54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (20924975..20926147, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (20924975..20926147, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA replication factor A complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: replication protein A2

Names: CG9273-PA; CG9273-PB; RPA2-PA; RPA2-PB; drosophila replication protein A; replication protein A 30; replication protein A, subunit 2; single stranded-binding protein 30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

20924975..20926147 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136233.3 → NP_610077.1 replication protein A2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610077.1

Status: REVIEWED

UniProtKB/TrEMBL

C0MJ04, Q8T9K0, Q9VIH1

Related

FBpp0080967

Conserved Domains (3) summary

COG5235
Location:12 → 246

RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]

cd04478
Location:52 → 144

RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...

pfam08784
Location:182 → 238

RPA_C; Replication protein A C terminal
NM_001273723.1 → NP_001260652.1 replication protein A2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260652.1

Status: REVIEWED

UniProtKB/TrEMBL

C0MJ04, Q8T9K0, Q9VIH1

Conserved Domains (3) summary

COG5235
Location:12 → 246

RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]

cd04478
Location:52 → 144

RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...

pfam08784
Location:182 → 238

RPA_C; Replication protein A C terminal