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    QDR1 multidrug transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854686, updated on 14-Nov-2024

    Summary

    Official Symbol
    QDR1
    Official Full Name
    multidrug transporter
    Primary source
    SGD:S000001382
    Locus tag
    YIL120W
    See related
    AllianceGenome:SGD:S000001382; FungiDB:YIL120W; VEuPathDB:YIL120W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables efflux transmembrane transporter activity. Involved in ascospore wall assembly and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See QDR1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (134417..136108)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Pog1p Neighboring gene cation transporter Neighboring gene Rpi1p Neighboring gene Rho family GTPase RHO3

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    multidrug transporter
    NP_012146.1
    • Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in spore wall assembly; sequence similarity to DTR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      134417..136108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179468.1NP_012146.1  TPA: multidrug transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVG7, P40475
      UniProtKB/TrEMBL
      N1P1X4
      Conserved Domains (1) summary
      cd17323
      Location:72516
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily