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    ALiX ALG-2 interacting protein X [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ALiXprovided by FlyBase
    Official Full Name
    ALG-2 interacting protein Xprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086346
    Locus tag
    Dmel_CG12876
    See related
    AllianceGenome:FB:FBgn0086346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aip1; AIP1; alix; Alix; AliX; ALIX; CG12876; DAIP1; Dmel\CG12876; Snf7
    Summary
    Involved in several processes, including actin filament polymerization; germline stem cell asymmetric division; and positive regulation of JNK cascade. Located in several cellular components, including centrosome; intercellular bridge; and midbody. Is expressed in adult head and female germline stem cell. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ALiX in Genome Data Viewer
    Location:
    98B1-98B1; 3-94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27696466..27700110, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23522188..23525832, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 98AB Neighboring gene HSPB1 associated protein 1 Neighboring gene barentsz Neighboring gene Carnitine O-octanoyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The multifunctional polydnavirus TnBVANK1 protein: impact on host apoptotic pathway. Salvia R, et al. Sci Rep, 2017 Sep 18. PMID 28924205, Free PMC Article
    2. ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo. Eikenes ÅH, et al. PLoS Genet, 2015 Jan. PMID 25635693, Free PMC Article
    3. POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. Tsuda M, et al. FEBS Lett, 2006 May 29. PMID 16698022
    4. Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics. Malerød L, et al. EMBO J, 2018 Jul 2. PMID 29858227, Free PMC Article
    5. Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding. Lie-Jensen A, et al. Curr Biol, 2019 Oct 21. PMID 31607533

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding.
      Title: Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding.
    2. Our results demonstrate a novel evolutionarily conserved role of ALIX in providing robustness to the orientation of the mitotic spindle by promoting astral microtubule formation during asymmetric and symmetric cell division.
      Title: Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics.
    3. We conclude that ALIX and ESCRT-III coordinately control abscission in Drosophila fGSCs and that their complex formation is required for accurate abscission timing in GSCs in vivo.
      Title: ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exosomal secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ALG-2 interacting protein X
    Names
    ALG-2 interacting protein 1
    ALiX-PA
    CG12876-PA
    apoptosis linked gene 2 interacting X

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27696466..27700110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143325.4 → NP_651582.1  ALG-2 interacting protein X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651582.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VB05
      Related
      FBpp0084610
      Conserved Domains (4) summary
      cd09235
      Location:362 → 698
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:2 → 347
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam07777
      Location:733 → 822
      MFMR; G-box binding protein MFMR
      pfam13949
      Location:415 → 701
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB05 Q9VB05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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