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    l(2)37Cb lethal (2) 37Cb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)37Cbprovided by FlyBase
    Official Full Name
    lethal (2) 37Cbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086444
    Locus tag
    Dmel_CG10689
    See related
    AllianceGenome:FB:FBgn0086444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cb; cg10689; CG10689; Dmel\CG10689; l(2)E104
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human DHX16 (DEAH-box helicase 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)37Cb in Genome Data Viewer
    Location:
    37C1-37C1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19123998..19126976, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19123998..19126976, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dopa decarboxylase Neighboring gene Prohibitin 1 Neighboring gene lethal (2) 37Cd Neighboring gene Asparaginyl-tRNA synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental control of transduced dopa decarboxylase genes in D. melanogaster. Marsh JL, et al. Mol Gen Genet, 1985. PMID 2989656
    2. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
    3. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region. Pentz ES, et al. Genetics, 1986 Apr. PMID 3007281, Free PMC Article
    4. Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. Gilbert D, et al. Genetics, 1984 Apr. PMID 6425116, Free PMC Article
    5. The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region. Wright TR, et al. Chromosoma, 1981. PMID 6790250

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lethal (2) 37Cb
    Names
    CG10689-PA
    l(2)37Cb-PA
    NP_609946.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19123998..19126976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136102.4 → NP_609946.1  lethal (2) 37Cb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIZ3
      Related
      FBpp0080706
      Conserved Domains (5) summary
      smart00490
      Location:491 → 581
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:651 → 735
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:222 → 867
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:269 → 408
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:770 → 869
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIZ3 Q9VIZ3

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