put punt [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: putprovided by FlyBase
Official Full Name: puntprovided by FlyBase
Primary source: FLYBASE:FBgn0003169
Locus tag: Dmel_CG7904
See related: AllianceGenome:FB:FBgn0003169
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Act-r; Atr; Atr-II; Atr88CD; atrII; AtrII; CG7904; dlhC; Dmel\CG7904; l(3)10460; l(3)j5A5; pun; Punt; PUNT; Put; STK-C; TGF-B; TGF-beta; Tgf-r
Summary: Enables activin binding activity and transmembrane receptor protein serine/threonine kinase activity. Contributes to BMP binding activity. Involved in several processes, including embryonic morphogenesis; transforming growth factor beta receptor superfamily signaling pathway; and wing disc development. Part of BMP receptor complex and activin receptor complex. Is active in basolateral plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; gut section; and mesoderm. Used to study juvenile polyposis syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome; colon cancer; and visceral heterotaxy. Orthologous to human ACVR2A (activin A receptor type 2A) and ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88C9-88C9; 3-55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14619030..14625703, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10444752..10451425, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that members of the Activin branch of the TGFbeta signaling pathway, namely Put and Smad2, are autonomously required for cell and tissue growth in the Drosophila larval salivary gland.
Title: TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands.
requirements for TGFbeta signalling during wing disc development
Title: Activation and function of TGFβ signalling during Drosophila wing development and its interactions with the BMP pathway.
In the absence of Smad2, aberrant Activin receptor signaling disrupts tissue patterning by the BMP signaling pathway.
Title: Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements.
The combined activity of the TGF-beta target genes FoxK and Dfos is critical for the direct activation of lab in the endoderm.
Title: FoxK mediates TGF-beta signalling during midgut differentiation in flies.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables BMP receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type II	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type II	IMP Inferred from Mutant Phenotype more info	PubMed
enables transforming growth factor beta receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of salivary gland boundary specification	TAS Traceable Author Statement more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BMP receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activin receptor complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: punt

Names: Activin-A-receptor-88CD; CG7904-PA; CG7904-PB; CG7904-PC; DPP receptor; TGF-beta-type-receptor-like; activin receptor; activin receptor type II; dorsal holes C; put-PA; put-PB; put-PC

NP_001262574.1

EC 2.7.11.30

NP_001262575.1

EC 2.7.11.30

NP_731926.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14619030..14625703 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275645.1 → NP_001262574.1 punt, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262574.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24229, Q24468

Conserved Domains (3) summary

smart00220
Location:210 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14053
Location:206 → 493

STKc_ACVR2; Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor

pfam01064
Location:38 → 126

Activin_recp; Activin types I and II receptor domain
NM_169591.3 → NP_731926.1 punt, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731926.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24229, Q24468

Related

FBpp0082436

Conserved Domains (3) summary

smart00220
Location:210 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14053
Location:206 → 493

STKc_ACVR2; Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor

pfam01064
Location:38 → 126

Activin_recp; Activin types I and II receptor domain
NM_001275646.1 → NP_001262575.1 punt, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262575.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG59, Q24229

Conserved Domains (3) summary

smart00220
Location:210 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14053
Location:206 → 493

STKc_ACVR2; Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor

pfam01064
Location:38 → 126

Activin_recp; Activin types I and II receptor domain