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    btz barentsz [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    btzprovided by FlyBase
    Official Full Name
    barentszprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045862
    Locus tag
    Dmel_CG12878
    See related
    AllianceGenome:FB:FBgn0045862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Btz; CG12878; Dmel\CG12878; wkl
    Summary
    Enables translation initiation factor binding activity. Involved in RNA splicing and oocyte axis specification. Located in neuronal ribonucleoprotein granule and nuclear envelope. Is expressed in several structures, including adult head; egg chamber; female germline cell; germarium region 2; and germarium region 2b. Orthologous to human CASC3 (CASC3 exon junction complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See btz in Genome Data Viewer
    Location:
    98B1-98B2; 3-94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27700361..27703445)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23526083..23529167)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Accessory gland protein 98AB Neighboring gene HSPB1 associated protein 1 Neighboring gene ALG-2 interacting protein X Neighboring gene Carnitine O-octanoyltransferase Neighboring gene uncharacterized protein Neighboring gene Ets at 98B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An exon junction complex-independent function of Barentsz in neuromuscular synapse growth.
      Title: An exon junction complex-independent function of Barentsz in neuromuscular synapse growth.
    2. identification of eIF4AIII and Barentsz as components of a conserved protein complex that is essential for mRNA localization in flies and nonsense-mediated mRNA decay in mammals
      Title: An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in bicoid mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    barentsz
    Names
    CG12878-PA
    CG12878-PB
    CG12878-PC
    CG12878-PD
    Dm SELOR
    barentz
    btz-PA
    btz-PB
    btz-PC
    btz-PD
    weak localizer

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27700361..27703445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276098.1 → NP_001263027.1  barentsz, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV40, Q9VB04
      Conserved Domains (2) summary
      smart01044
      Location:102 → 243
      Btz; CASC3/Barentsz eIF4AIII binding
      pfam12200
      Location:2 → 43
      DUF3597; Domain of unknown function (DUF3597)

    2. NM_001276099.1 → NP_001263028.1  barentsz, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263028.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH64, C8VV40
      Conserved Domains (2) summary
      smart01044
      Location:102 → 243
      Btz; CASC3/Barentsz eIF4AIII binding
      pfam12200
      Location:2 → 43
      DUF3597; Domain of unknown function (DUF3597)

    3. NM_079810.5 → NP_524534.1  barentsz, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV40, Q9VB04
      Related
      FBpp0084590
      Conserved Domains (2) summary
      smart01044
      Location:102 → 243
      Btz; CASC3/Barentsz eIF4AIII binding
      pfam12200
      Location:2 → 43
      DUF3597; Domain of unknown function (DUF3597)

    4. NM_170350.2 → NP_733229.2  barentsz, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733229.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV40, Q7KRX5
      Related
      FBpp0084591
      Conserved Domains (2) summary
      smart01044
      Location:123 → 264
      Btz; CASC3/Barentsz eIF4AIII binding
      pfam12200
      Location:23 → 64
      DUF3597; Domain of unknown function (DUF3597)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH64 A0A0B4KH64
    Q7KRX5 Q7KRX5
    Q960S3 Q960S3
    Q9VB04 Q9VB04

    Gene LinkOut

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