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    SFK1 Sfk1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853815, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SFK1
    Official Full Name
    Sfk1p
    Primary source
    SGD:S000001534
    Locus tag
    YKL051W
    See related
    AllianceGenome:SGD:S000001534; FungiDB:YKL051W; VEuPathDB:YKL051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in actin cytoskeleton organization; negative regulation of phospholipid translocation; and vacuole organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SFK1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (341312..342373)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mdm35p Neighboring gene Ask1p Neighboring gene Lpx2p Neighboring gene centromeric DNA-binding histone H3-like protein CSE4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. Butcher RA, et al. Chem Biol, 2003 Jun. PMID 12837385
    2. A heat-sensitive Osh protein controls PI4P polarity. Omnus DJ, et al. BMC Biol, 2020 Mar 13. PMID 32169085, Free PMC Article
    3. Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane. Kishimoto T, et al. Mol Biol Cell, 2021 Jul 15. PMID 34038161, Free PMC Article
    4. Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Audhya A, et al. Dev Cell, 2002 May. PMID 12015967
    5. Phospholipid flippases and Sfk1p, a novel regulator of phospholipid asymmetry, contribute to low permeability of the plasma membrane. Mioka T, et al. Mol Biol Cell, 2018 May 15. PMID 29540528, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane.
      Title: Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phospholipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sfk1p
    NP_012873.1
    • Protein that regulates phospholipid asymmetry at plasma membrane; may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      341312..342373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179617.1 → NP_012873.1  TPA: Sfk1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXN6, P35735
      UniProtKB/TrEMBL
      B3LR38, C7GP23, N1P7V7
      Conserved Domains (1) summary
      pfam10277
      Location:10 → 285
      Frag1; Frag1/DRAM/Sfk1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35735.1

    Gene LinkOut

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