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    NSR1 Nsr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853064, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NSR1
    Official Full Name
    Nsr1p
    Primary source
    SGD:S000003391
    Locus tag
    YGR159C
    See related
    AllianceGenome:SGD:S000003391; FungiDB:YGR159C; VEuPathDB:YGR159C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SHE5
    Summary
    Enables nuclear localization sequence binding activity and nucleic acid binding activity. Involved in DNA recombination and chromosome organization. Located in nuclear envelope. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) and NCL (nucleolin). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NSR1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (806412..807656, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene exosome non-catalytic core subunit MTR3 Neighboring gene Rts3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inheritance of suppressors of the drug sensitivity of a NSR1 deleted yeast strain. Zabetakis D. Yeast, 2000 Sep 15. PMID 10953086
    2. NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunits. Lee WC, et al. Mol Cell Biol, 1992 Sep. PMID 1508189, Free PMC Article
    3. Yeast NSR1 protein that has structural similarity to mammalian nucleolin is involved in pre-rRNA processing. Kondo K, et al. J Biol Chem, 1992 Aug 15. PMID 1644811
    4. Cold shock induction of yeast NSR1 protein and its role in pre-rRNA processing. Kondo K, et al. J Biol Chem, 1992 Aug 15. PMID 1644812
    5. Signal transduction. Unexpected mediators of protein phosphorylation. York JD, et al. Science, 2004 Dec 17. PMID 15604398

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming Sequence.
      Title: Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming Sequence.
    2. Studied and discovered 21 native sites of arginine methylation on five putative Hmt1 substrate proteins (Gar1p, Nop1p, Npl3p, Nsr1p, Rps2p).
      Title: Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p.
    3. Nsr1 and its interacting partner Top1 are polyphosphorylated.
      Title: Protein polyphosphorylation of lysine residues by inorganic polyphosphate.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-quadruplex DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-quadruplex DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nsr1p
    NP_011675.1
    • Nucleolin, nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; binds to G-quadruplex DNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by lysine polyphosphorylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      806412..807656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181288.1 → NP_011675.1  TPA: Nsr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011675.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUT9, P27476
      UniProtKB/TrEMBL
      C8Z953, N1P5Z5
      Conserved Domains (2) summary
      cd12447
      Location:169 → 244
      RRM1_gar2; RNA recognition motif 1 (RRM1) found in yeast protein gar2 and similar proteins
      cd12448
      Location:269 → 341
      RRM2_gar2; RNA recognition motif 2 (RRM2) found in yeast protein gar2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27476.1

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