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    ASK1 Ask1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853814, updated on 2-Nov-2024

    Summary

    Official Symbol
    ASK1
    Official Full Name
    Ask1p
    Primary source
    SGD:S000001535
    Locus tag
    YKL052C
    See related
    AllianceGenome:SGD:S000001535; FungiDB:YKL052C; VEuPathDB:YKL052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule plus-end binding activity. Involved in positive regulation of attachment of spindle microtubules to kinetochore and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ASK1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (339668..340546, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1 Neighboring gene Mdm35p Neighboring gene Sfk1p Neighboring gene Lpx2p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of DASH complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Ask1p
    NP_012872.2
    • Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      339668..340546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179618.1NP_012872.2  TPA: Ask1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012872.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXN5, P35734, Q68EC3, Q6B290
      UniProtKB/TrEMBL
      C7GP22, N1NZ83
      Conserved Domains (1) summary
      pfam08655
      Location:1073
      DASH_Ask1; DASH complex subunit Ask1