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    LOC1269950 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [ Anopheles gambiae (African malaria mosquito) ]

    Gene ID: 1269950, updated on 22-Jun-2024

    Summary

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    Gene symbol
    LOC1269950
    Gene description
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
    See related
    VectorBase:AGAMI1_000871
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Anopheles gambiae
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles
    Also known as
    AGAP007163
    Orthologs
    fruit fly all
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    Genomic context

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    See LOC1269950 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_12 current idAnoGambNW_F1_1 (GCF_943734735.2) 2 NC_064601.1 (112388480..112518965, complement)

    Chromosome 2 - NC_064601.1Genomic Context describing neighboring genes Neighboring gene protein lethal(2)essential for life Neighboring gene lethal (2) essential for life Neighboring gene collagenase Neighboring gene WD40 domain-containing protein denticleless

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_064601.1 Chromosome 2 Reference idAnoGambNW_F1_1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
    Names
    3',5'-cyclic-nucleotide phosphodiesterase
    AGAP007163-PA
    AGAP007163-PB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_943734735.2-RS_2023_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference idAnoGambNW_F1_1 Primary Assembly

    Genomic

    1. NC_064601.1 Reference idAnoGambNW_F1_1 Primary Assembly

      Range
      112388480..112518965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_308604.5 → XP_308604.5  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X5

    2. XM_061642250.1 → XP_061498234.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X2

    3. XM_061642255.1 → XP_061498239.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X4

    4. XM_061642245.1 → XP_061498229.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X1

    5. XM_061642256.1 → XP_061498240.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X4

    6. XM_061642248.1 → XP_061498232.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X1

    7. XM_061642247.1 → XP_061498231.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X1

    8. XM_061642261.1 → XP_061498245.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X2

    9. XM_061642257.1 → XP_061498241.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X4

    10. XM_061642259.1 → XP_061498243.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X5

    11. XM_061642246.1 → XP_061498230.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X1

    12. XM_061642258.1 → XP_061498242.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X4

    13. XM_061642249.1 → XP_061498233.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X1

    14. XM_061642266.1 → XP_061498250.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X8

    15. XM_061642265.1 → XP_061498249.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X8

    16. XM_061642260.1 → XP_061498244.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X6

    17. XM_061642264.1 → XP_061498248.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X7

    18. XM_061642268.1 → XP_061498252.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X10

    19. XM_061642271.1 → XP_061498255.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X10

    20. XM_061642269.1 → XP_061498253.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X10

    21. XM_061642267.1 → XP_061498251.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X10

    22. XM_061642270.1 → XP_061498254.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X10

    23. XM_061642251.1 → XP_061498235.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X3

    24. XM_061642254.1 → XP_061498238.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X3

    25. XM_061642253.1 → XP_061498237.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X3

    26. XM_001687977.2 → XP_001688029.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X9

      See identical proteins and their annotated locations for XP_001688029.1

      UniProtKB/TrEMBL
      A7URN7
      Conserved Domains (2) summary
      pfam00233
      Location:617 → 855
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam00989
      Location:285 → 386
      PAS; PAS fold
    Nucleotide Protein Strain
    Heading Accession and Version

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