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    PF3D7_1011900 heme oxygenase [ Plasmodium falciparum 3D7 ]

    Gene ID: 810274, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1011900
    Gene description
    heme oxygenase
    Locus tag
    PF3D7_1011900
    See related
    PlasmoDB:PF3D7_1011900; VEuPathDB:PF3D7_1011900
    Gene type
    protein coding
    RNA name
    heme oxygenase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1011900 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    6
    Sequence:
    Chromosome: 10; NC_037281.1 (460335..461993, complement)

    Chromosome 10 - NC_037281.1Genomic Context describing neighboring genes Neighboring gene DNA repair protein RAD23, putative Neighboring gene PRE-binding protein Neighboring gene RING zinc finger protein, putative Neighboring gene conserved protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037281.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum. Sigala PA, et al. J Biol Chem, 2012 Nov 2. PMID 22992734, Free PMC Article
    2. The novel heme oxygenase-like protein from Plasmodiumfalciparum converts heme to bilirubin IXalpha in the apicoplast. Okada K. FEBS Lett, 2009 Jan 22. PMID 19073183
    3. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that although PfHO (heme oxygenase (Decyclizing), PF10_0116) bound heme and protoporphyrin IX with modest affinity, it did not catalyze heme degradation.
      Title: Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum.
    2. The result of this study indicates that Pf heme oxygenase depends on reduced ferredoxin and a strong iron chelator for maximum activity.
      Title: The novel heme oxygenase-like protein from Plasmodiumfalciparum converts heme to bilirubin IXalpha in the apicoplast.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    NOT enables heme oxygenase (decyclizing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heme oxygenase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037281.1 Reference assembly

      Range
      460335..461993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001347365.2 → XP_001347401.2  heme oxygenase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001347401.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024V745, A0A024W701, A0A024X8E5, A0A0L7KFL4, A0A2I0BQM0, Q8IJS6, W4IG91, W4J3C7, W7ESL5
      Conserved Domains (1) summary
      cl15243
      Location:134 → 227
      HemeO-like; heme oxygenase
    Nucleotide Protein
    Heading Accession and Version

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