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    PF3D7_1132800 aquaglyceroporin [ Plasmodium falciparum 3D7 ]

    Gene ID: 810885, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1132800
    Gene description
    aquaglyceroporin
    Locus tag
    PF3D7_1132800
    See related
    PlasmoDB:PF3D7_1132800; VEuPathDB:PF3D7_1132800
    Gene type
    protein coding
    RNA name
    aquaglyceroporin
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1132800 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    1
    Sequence:
    Chromosome: 11; NC_037282.1 (1271204..1271980)

    Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA-splicing factor 38A, putative Neighboring gene 50S ribosomal protein L2, putative Neighboring gene glycine cleavage system H protein Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037282.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aquaglyceroporin PbAQP is required for efficient progression through the liver stage of Plasmodium infection. Promeneur D, et al. Sci Rep, 2018 Jan 12. PMID 29330527, Free PMC Article
    2. Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: involvement of the channel vestibules. Song J, et al. Biochim Biophys Acta, 2012 May. PMID 22326891
    3. Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Newby ZE, et al. Nat Struct Mol Biol, 2008 Jun. PMID 18500352, Free PMC Article
    4. Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei. Promeneur D, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17284593, Free PMC Article
    5. A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. Hansen M, et al. J Biol Chem, 2002 Feb 15. PMID 11729204

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PfAQP has high and EcGlpF low water permeability, and explain the inhibiting effect of sorbitol on PfAQP by its binding to the extracellular vestibule.
      Title: Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: involvement of the channel vestibules.
    2. 2.05-A resolution structure provides key evidence for the basis of water versus glycerol selectivity
      Title: Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables ammonium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosylglycerol transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within polyol transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cell surface HDA PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aquaglyceroporin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037282.1 Reference assembly

      Range
      1271204..1271980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001347973.3 → XP_001348009.1  aquaglyceroporin [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348009.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8II36, Q8WPZ6
      UniProtKB/TrEMBL
      A0A024UYN0, A0A024VW93, A0A024WN19, A0A024X7A3, A0A0L0D088, A0A0L1I716, A0A0L7KKB6, A0A0L7LWK6, W4IGD2, W4ISF9, W7FDG2, W7JLP7, W7K5E1
      Conserved Domains (1) summary
      PTZ00016
      Location:1 → 247
      PTZ00016; aquaglyceroporin; Provisional
    Nucleotide Protein
    Heading Accession and Version

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