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    PF3D7_1222700 glideosome-associated protein 45 [ Plasmodium falciparum 3D7 ]

    Gene ID: 811270, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1222700
    Gene description
    glideosome-associated protein 45
    Locus tag
    PF3D7_1222700
    See related
    PlasmoDB:PF3D7_1222700; VEuPathDB:PF3D7_1222700
    Gene type
    protein coding
    RNA name
    glideosome-associated protein 45
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1222700 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Sequence:
    Chromosome: 12; NC_037284.1 (918722..919336)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene diphthine--ammonia ligase, putative Neighboring gene AP2 domain transcription factor AP2-G Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress. Perrin AJ, et al. mBio, 2018 Jul 3. PMID 29970464, Free PMC Article
    2. Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development. Ridzuan MA, et al. PLoS One, 2012. PMID 22479457, Free PMC Article
    3. Functional dissection of the apicomplexan glideosome molecular architecture. Frénal K, et al. Cell Host Microbe, 2010 Oct 21. PMID 20951968
    4. Effects of calcium signaling on Plasmodium falciparum erythrocyte invasion and post-translational modification of gliding-associated protein 45 (PfGAP45). Jones ML, et al. Mol Biochem Parasitol, 2009 Nov. PMID 19576251, Free PMC Article
    5. A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. Baum J, et al. J Biol Chem, 2006 Feb 24. PMID 16321976

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results confirm the essential nature of GAP45 for invasion but show that Plasmodium falciparum does not require a functional motor complex to undergo egress from the red blood cell.
      Title: The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress.
    2. full length GAP45 labelled internally with GFP is assembled into the motor complex and transported to the developing inner membrane complex (IMC), in early schizogony, where it accumulates during intracellular development until merozoite release.
      Title: Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development.
    3. Knockout of the TgGAP45 gene revealed a profound impairment in parasite gliding, invasion, and egress.
      Title: Functional dissection of the apicomplexan glideosome molecular architecture.
    4. The serine/threonine kinase inhibitor, staurosporine, affects both PfGAP45 isoform distribution and the integrity of the glideosome complex.
      Title: Effects of calcium signaling on Plasmodium falciparum erythrocyte invasion and post-translational modification of gliding-associated protein 45 (PfGAP45).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in inner membrane pellicle complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in inner membrane pellicle complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glideosome-associated protein 45

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      918722..919336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350588.1 → XP_001350624.1  glideosome-associated protein 45 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350624.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8I5I8
      UniProtKB/TrEMBL
      A0A024V457, A0A024VMR9, A0A024VY85, A0A024WM65, A0A024X501, A0A0L7K9W3, W4I6F0, W4J2P0, W7F990, W7FV93, W7J8M2, W7K2V4
      Conserved Domains (1) summary
      PTZ00423
      Location:1 → 204
      PTZ00423; glideosome-associated protein 45; Provisional
    Nucleotide Protein
    Heading Accession and Version

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