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    PF3D7_1219600 aminophospholipid-transporting P-ATPase [ Plasmodium falciparum 3D7 ]

    Gene ID: 811242, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1219600
    Gene description
    aminophospholipid-transporting P-ATPase
    Locus tag
    PF3D7_1219600
    See related
    PlasmoDB:PF3D7_1219600; VEuPathDB:PF3D7_1219600
    Gene type
    protein coding
    RNA name
    aminophospholipid-transporting P-ATPase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1219600 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Sequence:
    Chromosome: 12; NC_037284.1 (785571..790673, complement)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene raf kinase inhibitor Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit. Lamy A, et al. Emerg Microbes Infect, 2021 Dec. PMID 33372863, Free PMC Article
    2. CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in Merozoite Egress and Trophozoite Maturation. Patel A, et al. mBio, 2022 Aug 30. PMID 35862778, Free PMC Article
    3. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Cowell AN, et al. Science, 2018 Jan 12. PMID 29326268, Free PMC Article
    4. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. Krogh A, et al. J Mol Biol, 2001 Jan 19. PMID 11152613
    5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminophospholipid-transporting P-ATPase
    XP_001350596.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      785571..790673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350560.1 → XP_001350596.1  aminophospholipid-transporting P-ATPase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350596.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024V410, A0A0L7KKD7, Q8I5L4, Q9U421, W7EY17, W7FRU8, W7JSC1
      Conserved Domains (1) summary
      TIGR01652
      Location:34 → 1497
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    Nucleotide Protein
    Heading Accession and Version

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