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    PF3D7_1228300 NIMA related kinase 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 811326, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1228300
    Gene description
    NIMA related kinase 1
    Locus tag
    PF3D7_1228300
    See related
    PlasmoDB:PF3D7_1228300; VEuPathDB:PF3D7_1228300
    Gene type
    protein coding
    RNA name
    NIMA related kinase 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1228300 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    2
    Sequence:
    Chromosome: 12; NC_037284.1 (1148111..1151461)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat protein Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene RNA pseudouridylate synthase, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases. Morahan BJ, et al. Commun Biol, 2020 Nov 20. PMID 33219324, Free PMC Article
    2. Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle. Dorin-Semblat D, et al. Microbiology (Reading), 2011 Oct. PMID 21757488, Free PMC Article
    3. Nima- and Aurora-related kinases of malaria parasites. Carvalho TG, et al. Biochim Biophys Acta, 2013 Jul. PMID 23462523
    4. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Oehring SC, et al. Genome Biol, 2012 Nov 26. PMID 23181666, Free PMC Article
    5. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies suggest that Nima- and Aurora-related kinases could be potential drug targets for antimalarial intervention.
      Title: Nima- and Aurora-related kinases of malaria parasites.
    2. Nek-1 is required for completion of the asexual cycle in red blood cells and that its expression in gametocytes.
      Title: Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    NIMA related kinase 1
    XP_001350680.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      1148111..1151461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350644.1 → XP_001350680.1  NIMA related kinase 1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350680.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0L1I9N7, A0A2I0BZB2, Q8I5D5
      Conserved Domains (1) summary
      PTZ00266
      Location:1 → 1057
      PTZ00266; NIMA-related protein kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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