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    PF3D7_1345100 thioredoxin 2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 813783, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1345100
    Gene description
    thioredoxin 2
    Locus tag
    PF3D7_1345100
    See related
    PlasmoDB:PF3D7_1345100; VEuPathDB:PF3D7_1345100
    Gene type
    protein coding
    RNA name
    thioredoxin 2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1345100 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    4
    Sequence:
    Chromosome: 13; NC_004331.3 (1809736..1810521, complement)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene rhomboid protease ROM6, putative Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery. Sharma A, et al. Sci Rep, 2011. PMID 22355694, Free PMC Article
    2. Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum. Boucher IW, et al. Mol Microbiol, 2006 Aug. PMID 16879648, Free PMC Article
    3. A newly discovered protein export machine in malaria parasites. de Koning-Ward TF, et al. Nature, 2009 Jun 18. PMID 19536257, Free PMC Article
    4. Compartmentation of redox metabolism in malaria parasites. Kehr S, et al. PLoS Pathog, 2010 Dec 23. PMID 21203490, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The P. falciparum mitochondrial peroxiredoxin is dependent on peroxidase with a preference for H2O2, and it has an important function in detoxification of reactive oxygen in the parasite's mitochondrion.
      Title: Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum.
    2. PfTrx-2 adopts a canonical thioredoxin fold but with significant structural differences in its N-terminus.
      Title: Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Component Evidence Code Pubs
    part_of PTEX complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      1809736..1810521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350130.1 → XP_001350166.1  thioredoxin 2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350166.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IDP4
      UniProtKB/TrEMBL
      W4IA74, W7F2S1, W7FZ55, W7JP69
      Conserved Domains (1) summary
      cd02947
      Location:69 → 154
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein
    Heading Accession and Version

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