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    PF3D7_1438400 metacaspase-2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 811945, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1438400
    Gene description
    metacaspase-2
    Locus tag
    PF3D7_1438400
    See related
    PlasmoDB:PF3D7_1438400; VEuPathDB:PF3D7_1438400
    Gene type
    protein coding
    RNA name
    metacaspase-2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1438400 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    7
    Sequence:
    Chromosome: 14; NC_037283.1 (1548918..1556721)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene tRNA-Sec Neighboring gene tRNA-Met Neighboring gene cleavage and polyadenylation specificity factor subunit 3, putative Neighboring gene conserved protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacaspase-2. Vandana, et al. Biochem J, 2020 Apr 17. PMID 32202613
    2. Biochemical characterization of unusual cysteine protease of P. falciparum, metacaspase-2 (MCA-2). Vandana, et al. Mol Biochem Parasitol, 2018 Mar. PMID 29317266
    3. Features of apoptosis in Plasmodium falciparum erythrocytic stage through a putative role of PfMCA1 metacaspase-like protein. Meslin B, et al. J Infect Dis, 2007 Jun 15. PMID 17492602
    4. A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites. Birnbaum J, et al. Science, 2020 Jan 3. PMID 31896710
    5. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metacaspase-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      1548918..1556721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348501.2 → XP_001348537.2  metacaspase-2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348537.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IL84
      UniProtKB/TrEMBL
      A0A2I0C1U7, W4IW54
    Nucleotide Protein
    Heading Accession and Version

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