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    PF3D7_0217500 calcium-dependent protein kinase 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812762, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0217500
    Gene description
    calcium-dependent protein kinase 1
    Locus tag
    PF3D7_0217500
    See related
    PlasmoDB:PF3D7_0217500; VEuPathDB:PF3D7_0217500
    Gene type
    protein coding
    RNA name
    calcium-dependent protein kinase 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0217500 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_037280.1 (720437..722661)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene AP-2 complex subunit sigma, putative Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene E2F-associated phosphoprotein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development. Azevedo MF, et al. Biochem J, 2013 Jun 15. PMID 23548171
    2. Calcium-binding properties of a calcium-dependent protein kinase from Plasmodium falciparum and the significance of individual calcium-binding sites for kinase activation. Zhao Y, et al. Biochemistry, 1994 Mar 29. PMID 8142371
    3. Export of Plasmodium falciparum calcium-dependent protein kinase 1 to the parasitophorous vacuole is dependent on three N-terminal membrane anchor motifs. Möskes C, et al. Mol Microbiol, 2004 Nov. PMID 15491359
    4. Thousands of chemical starting points for antimalarial lead identification. Gamo FJ, et al. Nature, 2010 May 20. PMID 20485427
    5. Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion. Bansal A, et al. J Biol Chem, 2013 Jan 18. PMID 23204525, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. critical role in mosquito infection
      Title: PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection.
    2. Expression of the J-domain of Plasmodium falciparum CDPK1 results in the arrest of parasite development late in the cell cycle during early schizogony.
      Title: Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development.
    3. PfCDPK1 regulates microneme discharge, a key process in erythrocyte invasion by malaria parasites.
      Title: Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exit from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-dependent protein kinase 1
    XP_001349680.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      720437..722661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349644.1 → XP_001349680.1  calcium-dependent protein kinase 1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349680.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A143ZWW4, A0A2I0BVG8, P62343, P62344, Q27731
      UniProtKB/TrEMBL
      A0A0L1I603, A0A8S9VSN6
      Conserved Domains (2) summary
      PTZ00184
      Location:369 → 515
      PTZ00184; calmodulin; Provisional
      cd05117
      Location:56 → 324
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62344.2

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