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    PF3D7_0207500 serine repeat antigen 6 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812667, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0207500
    Gene description
    serine repeat antigen 6
    Locus tag
    PF3D7_0207500
    See related
    PlasmoDB:PF3D7_0207500; VEuPathDB:PF3D7_0207500
    Gene type
    protein coding
    RNA name
    serine repeat antigen 6
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0207500 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_037280.1 (298897..302564, complement)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene serine repeat antigen 8 Neighboring gene serine repeat antigen 7 Neighboring gene serine repeat antigen 5 Neighboring gene serine repeat antigen 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor. Tan MSY, et al. EMBO J, 2021 Jun 1. PMID 33932049, Free PMC Article
    2. A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells. Thomas JA, et al. Nat Microbiol, 2018 Apr. PMID 29459732, Free PMC Article
    3. Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte. Ruecker A, et al. J Biol Chem, 2012 Nov 2. PMID 22984267, Free PMC Article
    4. A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. Miller SK, et al. J Biol Chem, 2002 Dec 6. PMID 12228245
    5. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Science, 1998 Nov 6. PMID 9804551

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that cysteine protease SERA6 localizes to the parasitophorous vacuole (PV) where it is precisely cleaved just prior to egress by an essential serine protease PfSUB1.
      Title: Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exit from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in symbiont-containing vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine repeat antigen 6
    XP_001349585.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      298897..302564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349549.2 → XP_001349585.2  serine repeat antigen 6 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349585.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9TY96
      UniProtKB/TrEMBL
      A0A0E3VL29, A0A0E4B386, A0A0E4B3C7, A0A0E4B3H8, A0A0E4FHY3, A0A2I0BVC7
      Conserved Domains (1) summary
      PTZ00462
      Location:101 → 1031
      PTZ00462; Serine-repeat antigen protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TY96.3

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