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    PF3D7_0315100 eukaryotic translation initiation factor 4E [ Plasmodium falciparum 3D7 ]

    Gene ID: 814464, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0315100
    Gene description
    eukaryotic translation initiation factor 4E
    Locus tag
    PF3D7_0315100
    See related
    PlasmoDB:PF3D7_0315100; VEuPathDB:PF3D7_0315100
    Gene type
    protein coding
    RNA name
    eukaryotic translation initiation factor 4E
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0315100 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_000521.4 (612739..613422, complement)

    Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene zinc finger protein, putative Neighboring gene circumsporozoite- and TRAP-related protein Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000521.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status. Shaw PJ, et al. Mol Biochem Parasitol, 2007 Oct. PMID 17692399
    2. Isolation and functional characterization of eIF4F components and poly(A)-binding protein from Plasmodium falciparum. Tuteja R, et al. Parasitol Int, 2009 Dec. PMID 19751846
    3. Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development. Mair GR, et al. PLoS Pathog, 2010 Feb 12. PMID 20169188, Free PMC Article
    4. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, et al. Nature, 1999 Aug 5. PMID 10448855
    5. Identification of Plasmodium falciparum nuclear proteins by mass spectrometry and proposed protein annotation. Briquet S, et al. PLoS One, 2018. PMID 30379851, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our studies indicate that PfeIF4E is involved in translation.
      Title: Isolation and functional characterization of eIF4F components and poly(A)-binding protein from Plasmodium falciparum.
    2. Study investigated the parasite eIF4E and its interaction with capped mRNA and demonstrated that it has canonical mRNA cap binding activity.
      Title: Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000521.4 Reference assembly

      Range
      612739..613422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351184.1 → XP_001351220.1  eukaryotic translation initiation factor 4E [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351220.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VCS8, A0A024VVA3, A0A024WD52, A0A024WVU5, A0A024XDP9, A0A0L1I9D3, A0A0L7K7J5, A0MTS9, O97266, W4INE7, W4IS68, W7FJI3, W7G4L5, W7JUX0, W7K024
      Conserved Domains (1) summary
      PTZ00040
      Location:1 → 227
      PTZ00040; translation initiation factor E4; Provisional
    Nucleotide Protein
    Heading Accession and Version

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