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    PF3D7_0532400 lysine-rich membrane-associated PHISTb protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 813130, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0532400
    Gene description
    lysine-rich membrane-associated PHISTb protein
    Locus tag
    PF3D7_0532400
    See related
    PlasmoDB:PF3D7_0532400; VEuPathDB:PF3D7_0532400
    Gene type
    protein coding
    RNA name
    lysine-rich membrane-associated PHISTb protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0532400 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_004326.2 (1312471..1314154)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene Plasmodium exported protein (PHISTc), unknown function Neighboring gene Plasmodium exported protein (PHISTb), unknown function Neighboring gene Plasmodium exported protein, unknown function Neighboring gene Plasmodium exported protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A lysine-rich membrane-associated PHISTb protein involved in alteration of the cytoadhesive properties of Plasmodium falciparum-infected red blood cells. Proellocks NI, et al. FASEB J, 2014 Jul. PMID 24706359
    2. The Plasmodium PHIST and RESA-Like Protein Families of Human and Rodent Malaria Parasites. Moreira CK, et al. PLoS One, 2016. PMID 27022937, Free PMC Article
    3. Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton. Oberli A, et al. Cell Microbiol, 2016 Oct. PMID 26916885, Free PMC Article
    4. A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface. Oberli A, et al. FASEB J, 2014 Oct. PMID 24983468, Free PMC Article
    5. Proteome and Structural Organization of the Knob Complex on the Surface of the Plasmodium Infected Red Blood Cell. Alampalli SV, et al. Proteomics Clin Appl, 2018 Jul. PMID 28981210

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PFE1605w does not play a role in PfEMP1 transport, but it directly interacts with both the intracellular segment of PfEMP1 and with cytoskeletal components.
      Title: Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adhesion of symbiont to microvasculature IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in infected host cell surface knob IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    lysine-rich membrane-associated PHISTb protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      1312471..1314154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351836.1 → XP_001351872.1  lysine-rich membrane-associated PHISTb protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351872.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024WCA0, Q8I3F0, W7JGG7, W7JZ56
      Conserved Domains (2) summary
      PTZ00121
      Location:446 → 527
      PTZ00121; MAEBL; Provisional
      PTZ00341
      Location:1 → 289
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    Nucleotide Protein
    Heading Accession and Version

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