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    PIG2 putative protein phosphatase regulator PIG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854766, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PIG2
    Official Full Name
    putative protein phosphatase regulator PIG2
    Primary source
    SGD:S000001307
    Locus tag
    YIL045W
    See related
    AllianceGenome:SGD:S000001307; FungiDB:YIL045W; VEuPathDB:YIL045W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable glycogen binding activity; protein phosphatase 1 binding activity; and protein phosphatase regulator activity. Involved in regulation of glycogen biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to several human genes including PPP1R3A (protein phosphatase 1 regulatory subunit 3A); PPP1R3B (protein phosphatase 1 regulatory subunit 3B); and PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PIG2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (271161..272777)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 Neighboring gene GTPase-activating protein AGE2 Neighboring gene cytochrome-b5 reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Cheng C, et al. Yeast, 1997 Jan. PMID 9046081
    2. Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae. Williams-Hart T, et al. Genetics, 2002 Apr. PMID 11973298, Free PMC Article
    3. Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Castermans D, et al. Cell Res, 2012 Jun. PMID 22290422, Free PMC Article
    4. The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair. Tronnersjö S, et al. Mol Genet Genomics, 2007 Jan. PMID 17043893
    5. Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Wilson WA, et al. Mol Cell Proteomics, 2002 Mar. PMID 12096123

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative protein phosphatase regulator PIG2
    NP_012219.3
    • Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      271161..272777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179395.3 → NP_012219.3  TPA: putative protein phosphatase regulator PIG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012219.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVN7, E9P960, P40187
      UniProtKB/TrEMBL
      A6ZVM4, B3LTQ1, B5VKQ2, N1P950
      Conserved Domains (1) summary
      pfam03370
      Location:388 → 508
      CBM_21; Carbohydrate/starch-binding module (family 21)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40187.1

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