SNU13 RNA binding protein SNU13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNU13
Official Full Name: RNA binding protein SNU13
Primary source: SGD:S000000752
Locus tag: YEL026W
See related: AllianceGenome:SGD:S000000752; FungiDB:YEL026W; VEuPathDB:YEL026W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables U3 snoRNA binding activity and U4 snRNA binding activity. Involved in mRNA splicing, via spliceosome and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of U4/U6 x U5 tri-snRNP complex; box C/D methylation guide snoRNP complex; and small-subunit processome. Used to study cancer. Orthologous to human SNU13 (small nuclear ribonucleoprotein 13). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SNU13 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (101943..102323)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bcd1 is required for interactions with box C/D snoRNAs including RNA binding protein SNU13 (Snu13).
Title: A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis.
Rsa1p enhances Snu13p binding on the U3 box C/D small nucleolar RNA which is one key element of 90S pre-ribosome.
Title: Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly.
Identification of residues needed for Snu13p and Rsa1p interaction.
Title: Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly.
Sequence and structure requirements for efficient association of Rrp9p on the B/C motif were studied in yeast cells by expression of variant U3 snoRNAs and immunoselection assays.
Title: Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair.
The observed structural differences offer a possible explanation to the observed difference in RNA specificity between Snu13p and L7Ae.
Title: Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables U3 snoRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U4 snRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U4/U6 x U5 tri-snRNP complex	IDA Inferred from Direct Assay more info	PubMed
part_of box C/D methylation guide snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of box C/D methylation guide snoRNP complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of precatalytic spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA binding protein SNU13

NP_010888.1

RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

101943..102323

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178841.1 → NP_010888.1 TPA: RNA binding protein SNU13 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010888.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLM2, P39990

UniProtKB/TrEMBL

A6ZQS2, B3LRY9, C7GX16, C8Z6X1, G2WCK5, N1PA74

Conserved Domains (1) summary

cd21104
Location:5 → 126

SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13