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    Ccdc38 coiled-coil domain containing 38 [ Mus musculus (house mouse) ]

    Gene ID: 237465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc38provided by MGI
    Official Full Name
    coiled-coil domain containing 38provided by MGI
    Primary source
    MGI:MGI:2444738
    See related
    Ensembl:ENSMUSG00000036168 AllianceGenome:MGI:2444738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933417K05Rik
    Summary
    Enables ubiquitin-modified histone reader activity. Involved in acrosome assembly and sperm flagellum assembly. Located in several cellular components, including manchette; sperm flagellum; and sperm head. Orthologous to human CCDC38 (coiled-coil domain containing 38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 28.5), liver E14 (RPKM 4.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc38 in Genome Data Viewer
    Location:
    10 C2; 10 48.55 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93376451..93420189)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93540589..93584327)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene histidine ammonia lyase Neighboring gene STARR-positive B cell enhancer ABC_E8360 Neighboring gene STARR-seq mESC enhancer starr_27586 Neighboring gene amidohydrolase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6903 Neighboring gene RIKEN cDNA 4933408J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6904 Neighboring gene STARR-positive B cell enhancer ABC_E9800 Neighboring gene small nuclear ribonucleoprotein polypeptide F Neighboring gene STARR-seq mESC enhancer starr_27587 Neighboring gene netrin 4 Neighboring gene ribosomal protein L29 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characteristics of the testes-specific gene, Ccdc38, in mice. Lin SR, et al. Mol Med Rep, 2016 Aug. PMID 27278724
    2. Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice. Wang Y, et al. J Genet Genomics, 2024 Apr. PMID 37709195
    3. CCDC38 is required for sperm flagellum biogenesis and male fertility in mice. Zhang R, et al. Development, 2022 Jun 1. PMID 35587122
    4. CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Ma Y, et al. Cell Mol Life Sci, 2023 Dec 1. PMID 38038747, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice.
      Title: Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice.
    2. CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.
      Title: CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.
    3. these results suggest that Ccdc38 is a testes-specific gene, which may be important for mouse spermatogenesis.
      Title: Identification and characteristics of the testes-specific gene, Ccdc38, in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-modified histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of intraciliary anterograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm head IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359749.1 → NP_001346678.1  coiled-coil domain-containing protein 38 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124585, AK029803, AK030205, AV280828
      Consensus CDS
      CCDS88074.1
      Related
      ENSMUSP00000150407.2, ENSMUST00000132214.8
      Conserved Domains (1) summary
      pfam13863
      Location:12 → 130
      DUF4200; Domain of unknown function (DUF4200)

    2. NM_175488.6 → NP_780697.2  coiled-coil domain-containing protein 38 isoform 1

      See identical proteins and their annotated locations for NP_780697.2

      Status: VALIDATED

      Source sequence(s)
      AC124585
      Consensus CDS
      CCDS24127.1
      UniProtKB/Swiss-Prot
      Q8CDD6, Q8CDE1, Q8CDN8
      Related
      ENSMUSP00000089860.6, ENSMUST00000092215.6
      Conserved Domains (1) summary
      pfam13863
      Location:112 → 230
      DUF4200; Domain of unknown function (DUF4200)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93376451..93420189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513628.4 → XP_006513691.1  coiled-coil domain-containing protein 38 isoform X1

      Conserved Domains (1) summary
      pfam13863
      Location:112 → 230
      DUF4200; Domain of unknown function (DUF4200)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDN8.1 GenPept UniProtKB/Swiss-Prot:Q8CDN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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