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    VHR1 Vhr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854755, updated on 2-Nov-2024

    Summary

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    Official Symbol
    VHR1
    Official Full Name
    Vhr1p
    Primary source
    SGD:S000001318
    Locus tag
    YIL056W
    See related
    AllianceGenome:SGD:S000001318; FungiDB:YIL056W; VEuPathDB:YIL056W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to biotin starvation and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See VHR1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (249991..251913)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Rgi2p Neighboring gene tRNA-Ser Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mechanism for target gene-specific SWI/SNF recruitment via the Snf2p N-terminus. Weider M, et al. Nucleic Acids Res, 2011 May. PMID 21278159, Free PMC Article
    2. Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5. Weider M, et al. J Biol Chem, 2006 May 12. PMID 16533810
    3. A yeast model of FUS/TLS-dependent cytotoxicity. Ju S, et al. PLoS Biol, 2011 Apr. PMID 21541368, Free PMC Article
    4. A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance. Michel S, et al. BMC Genet, 2015 Feb 11. PMID 25887987, Free PMC Article
    5. Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA. Akdoğan E, et al. PLoS One, 2016. PMID 26751567, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transaldolase TAL1 paralogue NQM1 and the transcription factor VHR1 interact haploproficiently and affect yeast stationary phase survival.
      Title: A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance.
    2. The presented data characterize Vhr1p as an essential component of the biotin-dependent signal transduction cascade in yeast.
      Title: Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to biotin starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vhr1p
    NP_012208.1
    • Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      249991..251913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179406.1 → NP_012208.1  TPA: Vhr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVM6, P40522
      UniProtKB/TrEMBL
      A6ZVL4, G2WG90
      Conserved Domains (1) summary
      pfam04001
      Location:16 → 97
      Vhr1; Transcription factor Vhr1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40522.1

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