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    NEM1 Nem1-Spo7 phosphatase catalytic subunit NEM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856393, updated on 14-Nov-2024

    Summary

    Official Symbol
    NEM1
    Official Full Name
    Nem1-Spo7 phosphatase catalytic subunit NEM1
    Primary source
    SGD:S000001046
    Locus tag
    YHR004C
    See related
    AllianceGenome:SGD:S000001046; FungiDB:YHR004C; VEuPathDB:YHR004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to phosphoprotein phosphatase activity. Involved in lipid droplet formation; nuclear envelope organization; and regulation of lipid biosynthetic process. Located in endoplasmic reticulum; lipid droplet; and membrane. Part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See NEM1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (111754..113094, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene coenzyme A transporter Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene guanine nucleotide-binding protein subunit alpha Neighboring gene protein transporter TIM10

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Nem1-Spo7 phosphatase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Nem1-Spo7 phosphatase catalytic subunit NEM1
    NP_011867.1
    • Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear/ER membrane association and activation of Pah1p, a phosphatidate phosphatase involved in the production of diacylglycerol DAG for lipid droplet biogenesis; regulates nuclear growth by controlling phospholipid biosynthesis; required for normal nuclear envelope morphology and sporulation; phosphatase activity of the Nem1p-Spo7p complex is inhibited by Ice2p; homolog of the human protein Dullard

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      111754..113094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179134.1NP_011867.1  TPA: Nem1-Spo7 phosphatase catalytic subunit NEM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011867.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKU7, P38757
      UniProtKB/TrEMBL
      B3LSC2, B5VJT0, C8ZA70
      Conserved Domains (1) summary
      COG5190
      Location:9446
      FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]