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    MAS2 mitochondrial-processing protease subunit alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856419, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MAS2
    Official Full Name
    mitochondrial-processing protease subunit alpha
    Primary source
    SGD:S000001066
    Locus tag
    YHR024C
    See related
    AllianceGenome:SGD:S000001066; FungiDB:YHR024C; VEuPathDB:YHR024C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MIF2
    Summary
    Contributes to metalloendopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 2. Orthologous to human PMPCA (peptidase, mitochondrial processing subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MAS2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (157744..159192, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene myosin 1 Neighboring gene homoserine kinase Neighboring gene H(+)-transporting V0 sector ATPase subunit c''

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycine-rich loop of mitochondrial processing peptidase alpha-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20. Dvoráková-Holá K, et al. J Mol Biol, 2010 Mar 12. PMID 20053354
    2. The processing peptidase of yeast mitochondria: the two co-operating components MPP and PEP are structurally related. Pollock RA, et al. EMBO J, 1988 Nov. PMID 3061797, Free PMC Article
    3. Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit. Jensen RE, et al. EMBO J, 1988 Dec 1. PMID 3061808, Free PMC Article
    4. Cooperative formation of a substrate binding pocket by alpha- and beta-subunits of mitochondrial processing peptidase. Kojima K, et al. J Biol Chem, 1998 Dec 4. PMID 9829989
    5. A computational study of the glycine-rich loop of mitochondrial processing peptidase. Kučera T, et al. PLoS One, 2013. PMID 24058582, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mas1-expressing cells exert a response to balance the proteotoxic stress induced by MPP dysfunction.
      Title: Quantitative Profiling for Substrates of the Mitochondrial Presequence Processing Protease Reveals a Set of Nonsubstrate Proteins Increased upon Proteotoxic Stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing involved in protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial processing peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial-processing protease subunit alpha
    NP_011889.1
    • Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      157744..159192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179154.1 → NP_011889.1  TPA: mitochondrial-processing protease subunit alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011889.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKX1, P11914
      UniProtKB/TrEMBL
      A6ZST0, B3LSE5, C7GTV6, C8ZA92, G2WF95, N1P1I9
      Conserved Domains (1) summary
      COG0612
      Location:7 → 457
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11914.1

    Gene LinkOut

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