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    OTU2 Otu2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856373, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OTU2
    Official Full Name
    Otu2p
    Primary source
    SGD:S000001005
    Locus tag
    YHL013C
    See related
    AllianceGenome:SGD:S000001005; FungiDB:YHL013C; VEuPathDB:YHL013C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Located in cytoplasm. Orthologous to several human genes including OTUD6A (OTU deubiquitinase 6A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See OTU2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (77430..78353, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S20 Neighboring gene Ylf2p Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene ribose phosphate diphosphokinase subunit PRS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Makarova KS, et al. Trends Biochem Sci, 2000 Feb. PMID 10664582
    2. The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation. Takehara Y, et al. iScience, 2021 Mar 19. PMID 33665564, Free PMC Article
    3. Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains. Isasa M, et al. J Proteome Res, 2015 Dec 4. PMID 26503604, Free PMC Article
    4. Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Rumpf S, et al. Mol Cell, 2006 Jan 20. PMID 16427015
    5. A balance of deubiquitinating enzymes controls cell cycle entry. Mapa CE, et al. Mol Biol Cell, 2018 Nov 15. PMID 30207830, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Otu2p
    NP_011850.1
    • hypothetical protein; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      77430..78353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179093.1 → NP_011850.1  TPA: Otu2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKQ0, P38747
      UniProtKB/TrEMBL
      A6ZSN9, B3LSA6, B5VJR7, C7GIS4, C8ZA53, G2WF54, N1P1E6
      Conserved Domains (1) summary
      COG5539
      Location:1 → 306
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38747.1

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