U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SMY1 Smy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853783, updated on 2-Nov-2024

    Summary

    Official Symbol
    SMY1
    Official Full Name
    Smy1p
    Primary source
    SGD:S000001562
    Locus tag
    YKL079W
    See related
    AllianceGenome:SGD:S000001562; FungiDB:YKL079W; VEuPathDB:YKL079W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cytoskeletal motor activity. Involved in vesicle docking involved in exocytosis. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Used to study amyotrophic lateral sclerosis and hereditary spastic paraplegia 10. Human ortholog(s) of this gene implicated in several diseases, including amyotrophic lateral sclerosis type 25; autoimmune disease (multiple); complex cortical dysplasia with other brain malformations 2; hereditary spastic paraplegia 10; and prostate cancer. Orthologous to human KIF5A (kinesin family member 5A); KIF5B (kinesin family member 5B); and KIF5C (kinesin family member 5C). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SMY1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (286603..288573)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene translation elongation factor EF1B gamma Neighboring gene ncRNA Neighboring gene H(+)-transporting V1 sector ATPase subunit C Neighboring gene RNA helicase Neighboring gene Psg1p

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle docking involved in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mating projection tip HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Smy1p
    NP_012844.1
    • Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      286603..288573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179645.1NP_012844.1  TPA: Smy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK8, P32364
      UniProtKB/TrEMBL
      B3LR12, B5VM77, N1NZ58
      Conserved Domains (2) summary
      COG1196
      Location:254568
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01369
      Location:25364
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup