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    ERG11 sterol 14-demethylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856398, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ERG11
    Official Full Name
    sterol 14-demethylase
    Primary source
    SGD:S000001049
    Locus tag
    YHR007C
    See related
    AllianceGenome:SGD:S000001049; FungiDB:YHR007C; VEuPathDB:YHR007C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CYP51
    Summary
    Enables sterol 14-demethylase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Used to study Alzheimer's disease and prostate cancer. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ERG11 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (120091..121683, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Stp2p Neighboring gene uncharacterized protein Neighboring gene superoxide dismutase SOD2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-sterol structural probes of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae. Wright GD, et al. Biochim Biophys Acta, 1990 Aug 1. PMID 2198946
    2. Overexpression of Erg11p by the regulatable GAL1 promoter confers fluconazole resistance in Saccharomyces cerevisiae. Kontoyiannis DP, et al. Antimicrob Agents Chemother, 1999 Nov. PMID 10543768, Free PMC Article
    3. Evidence for recycling of cytochrome P450 sterol 14-demethylase from the cis-Golgi compartment to the endoplasmic reticulum (ER) upon saturation of the ER-retention mechanism. Homma K, et al. J Biochem, 2000 May. PMID 10788782
    4. Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161. Monk BC, et al. Antimicrob Agents Chemother, 2019 Jan. PMID 30397057, Free PMC Article
    5. Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase. Buckner FS, et al. Mol Biochem Parasitol, 2003 Dec. PMID 14599667

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three-Dimensional Visualization of APEX2-Tagged Erg11 in Saccharomyces cerevisiae Using Focused Ion Beam Scanning Electron Microscopy.
      Title: Three-Dimensional Visualization of APEX2-Tagged Erg11 in Saccharomyces cerevisiae Using Focused Ion Beam Scanning Electron Microscopy.
    2. molecular characterization of Erg11 including interactions with NADPH-cytochrome P450 reductase and role of Erg11 in antifungal resistance [REVIEW]
      Title: Cytochrome P450 lanosterol 14α-demethylase (CYP51): insights from molecular genetic analysis of the ERG11 gene in Saccharomyces cerevisiae.
    3. Loss of Dap1 is suppressed by elevated levels of Erg11 but not by increased heme biosynthesis.
      Title: Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol 14-demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol 14-demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol 14-demethylase
    NP_011871.1
    • Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      120091..121683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179137.1 → NP_011871.1  TPA: sterol 14-demethylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKV1, P10614
      UniProtKB/TrEMBL
      A6ZSR0, B3LSC7, B5VJT3, C7GMQ5, N1P1H0
      Conserved Domains (1) summary
      cd11042
      Location:83 → 521
      CYP51-like; cytochrome P450 family 51 and similar cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10614.1

    Gene LinkOut

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