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    LEU5 coenzyme A transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LEU5
    Official Full Name
    coenzyme A transporter
    Primary source
    SGD:S000001044
    Locus tag
    YHR002W
    See related
    AllianceGenome:SGD:S000001044; FungiDB:YHR002W; VEuPathDB:YHR002W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables coenzyme A transmembrane transporter activity. Involved in coenzyme A transport. Located in mitochondrial inner membrane. Used to study Graves' disease. Orthologous to human SLC25A16 (solute carrier family 25 member 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LEU5 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (108812..109885)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein related protein OSH7 Neighboring gene ubiquinol--cytochrome-c reductase subunit 10 Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene Nem1-Spo7 phosphatase catalytic subunit NEM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast LEU5 is a PET-like gene that is not essential for leucine biosynthesis. Drain P, et al. Mol Gen Genet, 1986 Sep. PMID 3020377
    2. The Saccharomyces cerevisiae gene YPR011c encodes a mitochondrial transporter of adenosine 5'-phosphosulfate and 3'-phospho-adenosine 5'-phosphosulfate. Todisco S, et al. Biochim Biophys Acta, 2014 Feb. PMID 24296033
    3. Identification of mitochondrial coenzyme a transporters from maize and Arabidopsis. Zallot R, et al. Plant Physiol, 2013 Jun. PMID 23590975, Free PMC Article
    4. The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix. Prohl C, et al. Mol Cell Biol, 2001 Feb. PMID 11158296, Free PMC Article
    5. Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae. Niu W, et al. PLoS Genet, 2008 Jul 11. PMID 18617996, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables coenzyme A transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables coenzyme A transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial coenzyme A transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme A transporter
    NP_011865.1
    • Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      108812..109885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179132.1 → NP_011865.1  TPA: coenzyme A transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKR9, P38702
      UniProtKB/TrEMBL
      A6ZSQ4, B3LSC0, C7GMR1, C8ZA68, G2WF68, N1P519
      Conserved Domains (2) summary
      PTZ00169
      Location:38 → 329
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:32 → 127
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38702.1

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