Trappc3 trafficking protein particle complex 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trappc3provided by MGI
Official Full Name: trafficking protein particle complex 3provided by MGI
Primary source: MGI:MGI:1351486
See related: Ensembl:ENSMUSG00000028847 AllianceGenome:MGI:1351486
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bet3; 1110058K12Rik
Summary: Acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi membrane and cytosol. Part of TRAPP complex. Is expressed in central nervous system; ganglia; olfactory epithelium; and thymus primordium. Orthologous to human TRAPPC3 (trafficking protein particle complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 47.0), CNS E14 (RPKM 41.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 60.23 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (126156198..126169676)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126262405..126275883)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together our findings indicate that BET3 plays an important role in the organization of the TRAPP complexes in both mammalian cells and yeast.
Title: mBET3 is required for the organization of the TRAPP complexes.
the crystal structure of mouse Bet3p (bet3), a conserved TRAPP component, reveals a dimeric structure with hydrophobic channels
Title: Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136539 (e-PCR)
- UniSTS:210521

AI835942 (e-PCR)
- UniSTS:179058

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	NAS Non-traceable Author Statement more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle coating	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAPP complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPP complex	ISO Inferred from Sequence Orthology more info
part_of TRAPPII protein complex	NAS Non-traceable Author Statement more info	PubMed
part_of TRAPPIII protein complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cis-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trafficking protein particle complex subunit 3

Names: Bet3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013718.2 → NP_038746.1 trafficking protein particle complex subunit 3

See identical proteins and their annotated locations for NP_038746.1

Status: PROVISIONAL

Source sequence(s)

BC003736

Consensus CDS

CCDS18647.1

UniProtKB/Swiss-Prot

O55013

UniProtKB/TrEMBL

Q3U9K9

Related

ENSMUSP00000030660.9, ENSMUST00000030660.9

Conserved Domains (1) summary

cd14942
Location:15 → 169

TRAPPC3_bet3; Bet3-TRAPPC3 subunit of the TRAPP complex