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    RTG1 Rtg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RTG1
    Official Full Name
    Rtg1p
    Primary source
    SGD:S000005428
    Locus tag
    YOL067C
    See related
    AllianceGenome:SGD:S000005428; FungiDB:YOL067C; VEuPathDB:YOL067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cellular response to oleic acid; mitochondria-nucleus signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTG1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (201985..202518, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene kinetochore-associated Ndc80 complex subunit NUF2 Neighboring gene histone deacetylase HST1 Neighboring gene bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2 Neighboring gene phosphoinositide 5-phosphatase INP54

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of genes encoding peroxisomal proteins in Saccharomyces cerevisiae is regulated by different circuits of transcriptional control. Kos W, et al. Biochim Biophys Acta, 1995 Oct 17. PMID 7578261
    2. RTG genes in yeast that function in communication between mitochondria and the nucleus are also required for expression of genes encoding peroxisomal proteins. Chelstowska A, et al. J Biol Chem, 1995 Jul 28. PMID 7629125
    3. RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae. Torelli NQ, et al. Free Radic Biol Med, 2015 Apr. PMID 25578655
    4. Metabolic profiling of retrograde pathway transcription factors rtg1 and rtg3 knockout yeast. Hashim Z, et al. Metabolites, 2014 Jul 8. PMID 25007314, Free PMC Article
    5. Genetic interaction between F-box motif encoding YDR131C and retrograde signaling-related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae. Shoket H, et al. J Biochem Mol Toxicol, 2021 Oct. PMID 34309121

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae.
      Title: RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae.
    2. Rtg1/3p, Gln3p, and Gat1p can be differentially regulated through different nutrient-sensing pathways, such as TOR and retrograde signaling, and by multiple factors, such as Lst8p, which is suggested to have a role in connecting the RTG and TOR pathways
      Title: Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression.
    3. Tor signaling and Mks1p phosphorylation regulate expression of Rtg1.Rtg3p-dependent target genes
      Title: Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oleic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondria-nucleus signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondria-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rtg1p
    NP_014574.1
    • Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      201985..202518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183322.1 → NP_014574.1  TPA: Rtg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014574.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W200, P32607, Q08228
      UniProtKB/TrEMBL
      A6ZNE3, B3LIZ3, B5VRI5, C7GK34, C8ZHP8, G2WMG7, N1NXP1
      Conserved Domains (1) summary
      cd11387
      Location:16 → 102
      bHLHzip_USF_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32607.2

    Gene LinkOut

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