Pcna proliferating cell nuclear antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcnaprovided by MGI
Official Full Name: proliferating cell nuclear antigenprovided by MGI
Primary source: MGI:MGI:97503
See related: Ensembl:ENSMUSG00000027342 AllianceGenome:MGI:97503
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus; nuclear lamina; and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; genitourinary system; jaw; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14.5 (RPKM 270.8), liver E14 (RPKM 268.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F2; 2 64.15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (132091206..132095100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (132249286..132253180, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.
Title: HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.
Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
Title: Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
The Functions of PCNA in Tumor Stemness and Invasion.
Title: The Functions of PCNA in Tumor Stemness and Invasion.
Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA.
Title: Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA.
Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
Title: Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
Evaluating the Effects of Different Concentrations of Human Follicular Fluid on Growth, Development, and PCNA Gene Expression of Mouse Ovarian Follicles.
Title: Evaluating the Effects of Different Concentrations of Human Follicular Fluid on Growth, Development, and PCNA Gene Expression of Mouse Ovarian Follicles.
Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.
Title: Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.
Silk Fibroin Promotes the Regeneration of Pancreatic beta-Cells in the C57BL/KsJ-Lepr(db/db) Mouse.
Title: Silk Fibroin Promotes the Regeneration of Pancreatic β-Cells in the C57BL/KsJ-Lepr(db/db) Mouse.
The first evidence for non-repair functions of MGMT in cell cycle and highlight the involvement of PCNA in MGMT downregulation, with p21 attenuating the process.
Title: S-phase Specific Downregulation of Human O(6)-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21(cip1) Proteins in Glioma Cells.
e results showed mTet1 modified mGSCs had better self-renewal and proliferation ability than wild-type mGSCs, mTet1 could also up-regulate JMJD3 to decrease H3K27me3, which also showed to suppress the MEK-ERK pathway. Furthermore, Co-IP analysis demonstrated that TET1 interact with PCNA and HDAC1 by forming protein complexes to comprehensively regulate dairy goat mGSCs and spermatogenesis.
Title: The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pcna (e-PCR), detects polymorphism
- UniSTS:144139

Pcna-ps2 (e-PCR), detects polymorphism
- UniSTS:144140

PMC133764P5 (e-PCR)
- UniSTS:270658

RH94484 (e-PCR)
- UniSTS:119732

RH128612 (e-PCR)
- UniSTS:211920

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables DNA polymerase processivity factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info
enables MutLalpha complex binding	IEA Inferred from Electronic Annotation more info
enables MutLalpha complex binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables dinucleotide insertion or deletion binding	IEA Inferred from Electronic Annotation more info
enables dinucleotide insertion or deletion binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables purine-specific mismatch base pair DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info
enables purine-specific mismatch base pair DNA N-glycosylase activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within base-excision repair, gap-filling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	ISO Inferred from Sequence Orthology more info
involved_in mitotic telomere maintenance via semi-conservative replication	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of deoxyribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of deoxyribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to L-glutamate	IEA Inferred from Electronic Annotation more info
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to lipid	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of PCNA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PCNA complex	ISO Inferred from Sequence Orthology more info
part_of PCNA complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PCNA-p21 complex	ISO Inferred from Sequence Orthology more info
part_of PCNA-p21 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear replication fork	IEA Inferred from Electronic Annotation more info
located_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in replication fork	IDA Inferred from Direct Assay more info	PubMed
located_in replication fork	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: proliferating cell nuclear antigen

Names: cyclin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011045.2 → NP_035175.1 proliferating cell nuclear antigen

See identical proteins and their annotated locations for NP_035175.1

Status: PROVISIONAL

Source sequence(s)

AL807793

Consensus CDS

CCDS16771.1

UniProtKB/Swiss-Prot

P17918

UniProtKB/TrEMBL

Q542J9, Q91ZH2

Related

ENSMUSP00000028817.7, ENSMUST00000028817.7

Conserved Domains (2) summary

cd00577
Location:4 → 256

PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...

TIGR00590
Location:1 → 259

pcna; proliferating cell nuclear antigen (pcna)