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    Slc22a13 solute carrier family 22 (organic cation transporter), member 13 [ Mus musculus (house mouse) ]

    Gene ID: 102570, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc22a13provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 13provided by MGI
    Primary source
    MGI:MGI:2143107
    See related
    Ensembl:ENSMUSG00000074028 AllianceGenome:MGI:2143107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OAT10; OCTL1; OCTL3; ORCTL3
    Summary
    Enables nicotinate transmembrane transporter activity. Involved in negative regulation of fatty acid metabolic process and nicotinate transport. Predicted to be located in Golgi apparatus; apical plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SLC22A13 (solute carrier family 22 member 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 69.2) See more
    Orthologs
    human all
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    Genomic context

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    See Slc22a13 in Genome Data Viewer
    Location:
    9 F3; 9 71.33 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119020618..119038171, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119192966..119209105, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide pseudogene Neighboring gene solute carrier family 22 (organic cation transporter), member 14 Neighboring gene STARR-seq mESC enhancer starr_25468 Neighboring gene STARR-seq mESC enhancer starr_25469 Neighboring gene solute carrier family 22 (organic cation transporter), member 13b Neighboring gene oxidative-stress responsive 1 Neighboring gene STARR-positive B cell enhancer ABC_E1119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119231914-119232305

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. Shinoda Y, et al. Drug Metab Pharmacokinet, 2022 Apr. PMID 35144162
    2. The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis. AbuAli G, et al. Oncogene, 2015 Mar 26. PMID 24769897, Free PMC Article
    3. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article
    4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nicotinate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nicotinate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nicotinate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in urate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 13
    Names
    ORCTL-3
    organic anion transporter 10
    organic cation transporter-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133980.3 → NP_598741.2  solute carrier family 22 member 13

      See identical proteins and their annotated locations for NP_598741.2

      Status: VALIDATED

      Source sequence(s)
      AC055818, AF529220, AI649135
      Consensus CDS
      CCDS40802.1
      UniProtKB/Swiss-Prot
      E9QP74, Q6A4L0, Q8VC89
      Related
      ENSMUSP00000081855.5, ENSMUST00000084797.6
      Conserved Domains (2) summary
      cd06174
      Location:139 → 500
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12 → 510
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119020618..119038171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511917.4 → XP_006511980.1  solute carrier family 22 member 13 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:1 → 356
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A4L0.3 GenPept UniProtKB/Swiss-Prot:Q6A4L0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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