Mrps2 mitochondrial ribosomal protein S2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrps2provided by MGI
Official Full Name: mitochondrial ribosomal protein S2provided by MGI
Primary source: MGI:MGI:2153089
See related: Ensembl:ENSMUSG00000035772 AllianceGenome:MGI:2153089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500019M10Rik
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial ribosome assembly and mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; heart; and liver. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 36. Orthologous to human MRPS2 (mitochondrial ribosomal protein S2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 23.2), adrenal adult (RPKM 20.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (28355963..28361189)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (28465951..28471177)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial ribosome assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ribosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitochondrial translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
part_of mitochondrial small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of mitochondrial small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small ribosomal subunit protein uS2m

Names: 28S ribosomal protein S2, mitochondrial; MRP-S2; S2mt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166031.2 → NP_001159503.2 small ribosomal subunit protein uS2m isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK051184, AK077219

UniProtKB/TrEMBL

Q8BQ99

Conserved Domains (1) summary

cd01425
Location:62 → 237

RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
NM_080452.3 → NP_536700.3 small ribosomal subunit protein uS2m isoform 1

See identical proteins and their annotated locations for NP_536700.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK051184, AK077219

Consensus CDS

CCDS15838.1

UniProtKB/Swiss-Prot

A2AK29, Q3TMF8, Q924T2

UniProtKB/TrEMBL

Q8BQ99

Related

ENSMUSP00000036725.4, ENSMUST00000038600.4

Conserved Domains (1) summary

cd01425
Location:81 → 256

RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

28355963..28361189

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497625.3 → XP_006497688.1 small ribosomal subunit protein uS2m isoform X1

See identical proteins and their annotated locations for XP_006497688.1

UniProtKB/TrEMBL

Q8BQ99

Conserved Domains (1) summary

cd01425
Location:127 → 302

RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
XM_030246830.1 → XP_030102690.1 small ribosomal subunit protein uS2m isoform X3

Related

ENSMUST00000146332.2

Conserved Domains (1) summary

cd01425
Location:1 → 158

RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
XM_036157666.1 → XP_036013559.1 small ribosomal subunit protein uS2m isoform X2

Conserved Domains (1) summary

cd01425
Location:3 → 160

RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
XM_036157667.1 → XP_036013560.1 small ribosomal subunit protein uS2m isoform X2

Conserved Domains (1) summary

cd01425
Location:3 → 160

RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...