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    Pabpc4 poly(A) binding protein, cytoplasmic 4 [ Mus musculus (house mouse) ]

    Gene ID: 230721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pabpc4provided by MGI
    Official Full Name
    poly(A) binding protein, cytoplasmic 4provided by MGI
    Primary source
    MGI:MGI:2385206
    See related
    Ensembl:ENSMUSG00000011257 AllianceGenome:MGI:2385206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables mRNA binding activity. Acts upstream of or within myeloid cell development and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in central nervous system; sensory organ; and tooth. Orthologous to human PABPC4 (poly(A) binding protein cytoplasmic 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 71.8), liver E14.5 (RPKM 71.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pabpc4 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.42 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123172722..123192718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123282303..123298925)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:122960063-122960364 Neighboring gene predicted gene, 50623 Neighboring gene predicted gene 12900 Neighboring gene STARR-positive B cell enhancer ABC_E2118 Neighboring gene predicted gene, 25788 Neighboring gene predicted gene, 22154 Neighboring gene STARR-seq mESC enhancer starr_11290 Neighboring gene bone morphogenetic protein 8a Neighboring gene 3-oxoacid CoA transferase 2A Neighboring gene microtubule-actin crosslinking factor 1 Neighboring gene predicted gene 12924

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. Oliveira AG, et al. J Biol Chem, 2023 Jun. PMID 37059182, Free PMC Article
    2. Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Kini HK, et al. Mol Cell Biol, 2014 Apr. PMID 24469397, Free PMC Article
    3. Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. Burgess HM, et al. J Cell Sci, 2011 Oct 1. PMID 21940797, Free PMC Article
    4. Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b. Onishi M, et al. Genomics, 2004 Apr. PMID 15028287
    5. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm Genome, 2013 Aug. PMID 23912999, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.
      Title: Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.
    2. selective depletion of PABPC4 in an erythroblast cell line inhibits terminal erythroid maturation with corresponding alterations in the erythroid gene expression
      Title: Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6685, MGC11665

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables poly(C) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within myeloid cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356377.1 → NP_001343306.1  polyadenylate-binding protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606917, BC056432
      UniProtKB/TrEMBL
      Q99LF8
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 611
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    2. NM_130881.3 → NP_570951.2  polyadenylate-binding protein 4 isoform 1

      See identical proteins and their annotated locations for NP_570951.2

      Status: VALIDATED

      Source sequence(s)
      AL606917, BC056432
      Consensus CDS
      CCDS18614.1
      UniProtKB/TrEMBL
      Q6PHQ9, Q99LF8
      Related
      ENSMUSP00000079070.7, ENSMUST00000080178.13
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 640
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:572 → 639
      PABP; Poly-adenylate binding protein, unique domain

    3. NM_148917.3 → NP_683717.1  polyadenylate-binding protein 4 isoform 2

      See identical proteins and their annotated locations for NP_683717.1

      Status: VALIDATED

      Source sequence(s)
      AL606917, BC056432
      Consensus CDS
      CCDS18615.1
      UniProtKB/TrEMBL
      Q91YZ8, Q99LF8
      Related
      ENSMUSP00000077794.6, ENSMUST00000078734.12
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 595
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:527 → 594
      PABP; Poly-adenylate binding protein, unique domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      123172722..123192718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503023.4 → XP_006503086.1  polyadenylate-binding protein 4 isoform X6

      Conserved Domains (1) summary
      TIGR01628
      Location:1 → 418
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    2. XM_030253447.2 → XP_030109307.1  polyadenylate-binding protein 4 isoform X9

      Conserved Domains (1) summary
      TIGR01628
      Location:1 → 389
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    3. XM_006503024.4 → XP_006503087.1  polyadenylate-binding protein 4 isoform X7

      Conserved Domains (1) summary
      TIGR01628
      Location:1 → 402
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    4. XM_036164042.1 → XP_036019935.1  polyadenylate-binding protein 4 isoform X10

      Conserved Domains (1) summary
      TIGR01628
      Location:1 → 373
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    5. XM_006503020.4 → XP_006503083.1  polyadenylate-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      Q99LF8
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 640
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    6. XM_006503022.4 → XP_006503085.1  polyadenylate-binding protein 4 isoform X4

      UniProtKB/TrEMBL
      A3KFU5, Q99LF8
      Related
      ENSMUSP00000101850.2, ENSMUST00000106243.8
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 611
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    7. XM_006503021.4 → XP_006503084.1  polyadenylate-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      A3KFU8, Q99LF8
      Related
      ENSMUSP00000101848.2, ENSMUST00000106241.8
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 624
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    8. XM_030253445.2 → XP_030109305.1  polyadenylate-binding protein 4 isoform X5

      UniProtKB/TrEMBL
      Q99LF8
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 595
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    9. XM_036164041.1 → XP_036019934.1  polyadenylate-binding protein 4 isoform X8

      Conserved Domains (1) summary
      TIGR01628
      Location:1 → 402
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    10. XM_030253444.2 → XP_030109304.1  polyadenylate-binding protein 4 isoform X3

      UniProtKB/TrEMBL
      Q99LF8
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 624
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    Nucleotide Protein Strain
    Heading Accession and Version

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