Pkdrej polycystin (PKD) family receptor for egg jelly [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pkdrejprovided by MGI
Official Full Name: polycystin (PKD) family receptor for egg jellyprovided by MGI
Primary source: MGI:MGI:1338786
See related: Ensembl:ENSMUSG00000052496 AllianceGenome:MGI:1338786
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable calcium channel activity. Acts upstream of or within regulation of acrosome reaction. Located in sperm plasma membrane. Is expressed in cochlea. Orthologous to human PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 15 E2; 15 40.42 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (85698877..85705934, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (85814676..85821733, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pkdrej controls the timing of fertilization in vivo through effects on sperm transport and exocytotic competence and is a factor in postcopulatory sexual selection.
Title: A polycystin-1 controls postcopulatory reproductive selection in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

Pkdrej (e-PCR), detects polymorphism
- UniSTS:531228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polycystin family receptor for egg jelly

Names: PKD and REJ homolog; polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin); polycystic kidney disease and receptor for egg jelly-related protein; receptor for egg jelly-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011105.2 → NP_035235.2 polycystin family receptor for egg jelly precursor

See identical proteins and their annotated locations for NP_035235.2

Status: VALIDATED

Source sequence(s)

AC117784

Consensus CDS

CCDS27723.1

UniProtKB/Swiss-Prot

F8VQF3, Q9Z0T6

Related

ENSMUSP00000086352.3, ENSMUST00000064370.6

Conserved Domains (3) summary

cd01752
Location:1115 → 1230

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam02010
Location:130 → 598

REJ; REJ domain

pfam08016
Location:1621 → 2051

PKD_channel; Polycystin cation channel