Usp27x ubiquitin specific peptidase 27, X chromosome [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp27xprovided by MGI
Official Full Name: ubiquitin specific peptidase 27, X chromosomeprovided by MGI
Primary source: MGI:MGI:1859645
See related: Ensembl:ENSMUSG00000046269 AllianceGenome:MGI:1859645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sfc11; Usp27
Summary: Enables K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Involved in positive regulation of apoptotic process; protein deubiquitination; and protein stabilization. Predicted to be located in cytosol and nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 105. Orthologous to human USP27X (ubiquitin specific peptidase 27 X-linked). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.31 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7238830..7242069, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7372591..7375830, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these studies uncover a novel negative regulatory role of USP27X in targeting RIG-I to balance innate immune responses.
Title: USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I.
Usp27x can trigger via its proteolytic activity the deubiquitination of Bim and enhance its levels, counteracting the anti-apoptotic effects of ERK activity, and therefore acts as a tumour suppressor.
Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

DXImx4 (e-PCR), detects polymorphism
- UniSTS:181868

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables K63-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 27

Names: X-linked ubiquitin carboxyl-terminal hydrolase 27; X-linked ubiquitin thioesterase 27; deubiquitinating enzyme 27; ubiquitin specific protease 27, X chromosome; ubiquitin thioesterase 27; ubiquitin thiolesterase 27; ubiquitin-specific-processing protease 27

NP_062334.2

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019461.4 → NP_062334.2 ubiquitin carboxyl-terminal hydrolase 27

See identical proteins and their annotated locations for NP_062334.2

Status: VALIDATED

Source sequence(s)

AL663104

Consensus CDS

CCDS52983.1

UniProtKB/Swiss-Prot

B1ATV2, Q8BSW2, Q8CEG8, Q9JIG5

Related

ENSMUSP00000111409.2, ENSMUST00000115744.2

Conserved Domains (2) summary

cd02660
Location:78 → 419

Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:77 → 418

UCH; Ubiquitin carboxyl-terminal hydrolase