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    Ctnnb1 catenin beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 12387, updated on 10-Dec-2024

    Summary

    Official Symbol
    Ctnnb1provided by MGI
    Official Full Name
    catenin beta 1provided by MGI
    Primary source
    MGI:MGI:88276
    See related
    Ensembl:ENSMUSG00000006932 AllianceGenome:MGI:88276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bfc; Mesc; Catnb
    Summary
    This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 116.8), limb E14.5 (RPKM 110.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ctnnb1 in Genome Data Viewer
    Location:
    9 F4; 9 72.19 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (120762466..120789573)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120933400..120960507)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020M21 gene Neighboring gene STARR-seq mESC enhancer starr_25514 Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene predicted gene, 38502 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:120870733-120870842 Neighboring gene microRNA 7090 Neighboring gene STARR-seq mESC enhancer starr_25518 Neighboring gene predicted gene, 34945 Neighboring gene unc-51-like kinase 4 Neighboring gene zinc finger protein 606 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 49
    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding PubMed 
    enables DNA-binding transcription factor binding  
    enables I-SMAD binding  
    enables I-SMAD binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables SMAD binding  
    enables alpha-catenin binding  
    enables alpha-catenin binding PubMed 
    enables alpha-catenin binding PubMed 
    enables alpha-catenin binding  
    enables cadherin binding  
    enables cadherin binding PubMed 
    enables cadherin binding PubMed 
    enables chromatin binding PubMed 
    enables chromatin binding PubMed 
    enables delta-catenin binding  
    enables disordered domain specific binding PubMed 
    enables enzyme binding PubMed 
    enables enzyme binding  
    enables histone methyltransferase binding PubMed 
    enables ionotropic glutamate receptor binding  
    enables kinase binding  
    enables molecular function activator activity PubMed 
    enables nitric-oxide synthase binding  
    enables nuclear estrogen receptor binding  
    enables nuclear estrogen receptor binding  
    enables nuclear receptor binding  
    enables nuclear receptor binding PubMed 
    enables nuclear receptor binding  
    enables nucleic acid binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein phosphatase binding  
    enables protein phosphatase binding PubMed 
    enables protein-containing complex binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity PubMed 
    enables transcription coactivator activity PubMed 
    enables transcription coactivator activity  
    enables transcription coregulator binding PubMed 
    enables transcription corepressor binding  
    enables transcription corepressor binding  
    enables transcription factor binding PubMed 
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 49
    Items 1 - 25 of 273
    Process Evidence Code Pubs
    acts_upstream_of DNA-templated transcription PubMed 
    acts_upstream_of MAPK cascade PubMed 
    involved_in Schwann cell proliferation  
    acts_upstream_of_or_within T cell differentiation PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within acinar cell differentiation PubMed 
    involved_in adherens junction assembly  
    involved_in adherens junction assembly  
    acts_upstream_of_or_within adherens junction organization PubMed 
    acts_upstream_of_or_within animal organ development PubMed 
    acts_upstream_of_or_within anterior/posterior axis specification PubMed 
    acts_upstream_of apoptotic signaling pathway PubMed 
    acts_upstream_of apoptotic signaling pathway PubMed 
    involved_in astrocyte-dopaminergic neuron signaling PubMed 
    acts_upstream_of_or_within bone resorption PubMed 
    acts_upstream_of_or_within bone resorption PubMed 
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis PubMed 
    involved_in branching involved in blood vessel morphogenesis  
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation PubMed 
    involved_in cardiac muscle cell proliferation PubMed 
    involved_in cardiac vascular smooth muscle cell differentiation PubMed 
    involved_in cell adhesion  
    involved_in cell adhesion  
    acts_upstream_of cell differentiation PubMed 
    acts_upstream_of_or_within cell fate specification PubMed 
    acts_upstream_of_or_within cell maturation PubMed 
    acts_upstream_of_or_within cell maturation PubMed 
    acts_upstream_of_or_within cell morphogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cell population proliferation PubMed 
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-cell adhesion PubMed 
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-matrix adhesion PubMed 
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to indole-3-methanol  
    involved_in cellular response to indole-3-methanol  
    involved_in cellular response to insulin-like growth factor stimulus  
    involved_in cellular response to mechanical stimulus  
    acts_upstream_of_or_within central nervous system vasculogenesis PubMed 
    acts_upstream_of_or_within chemical synaptic transmission PubMed 
    acts_upstream_of chondrocyte differentiation PubMed 
    acts_upstream_of chondrocyte differentiation PubMed 
    involved_in coronary artery morphogenesis PubMed 
    involved_in cranial ganglion development PubMed 
    involved_in cranial skeletal system development PubMed 
    involved_in dorsal root ganglion development PubMed 
    acts_upstream_of_or_within dorsal/ventral axis specification PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation PubMed 
    acts_upstream_of_or_within ectoderm development PubMed 
    acts_upstream_of_or_within embryonic axis specification PubMed 
    involved_in embryonic brain development PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    acts_upstream_of_or_within embryonic foregut morphogenesis PubMed 
    acts_upstream_of_or_within embryonic forelimb morphogenesis PubMed 
    acts_upstream_of_or_within embryonic heart tube development PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis PubMed 
    involved_in embryonic organ development PubMed 
    involved_in embryonic skeletal limb joint morphogenesis PubMed 
    acts_upstream_of_or_within endoderm formation PubMed 
    acts_upstream_of_or_within endodermal cell fate commitment PubMed 
    involved_in endothelial tube morphogenesis  
    involved_in endothelial tube morphogenesis  
    involved_in epicardium-derived cardiac vascular smooth muscle cell differentiation PubMed 
    acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development PubMed 
    acts_upstream_of epithelial cell proliferation involved in prostate gland development PubMed 
    acts_upstream_of epithelial tube branching involved in lung morphogenesis PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis PubMed 
    acts_upstream_of_or_within establishment of blood-brain barrier PubMed 
    acts_upstream_of_or_within establishment of blood-retinal barrier PubMed 
    acts_upstream_of fibroblast growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within forebrain development PubMed 
    acts_upstream_of_or_within fungiform papilla formation PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    acts_upstream_of_or_within genitalia morphogenesis PubMed 
    acts_upstream_of_or_within glandular epithelial cell differentiation PubMed 
    acts_upstream_of_or_within glial cell fate determination PubMed 
    acts_upstream_of_or_within hair cycle process PubMed 
    acts_upstream_of_or_within hair follicle morphogenesis PubMed 
    acts_upstream_of_or_within hair follicle placode formation PubMed 
    acts_upstream_of_or_within hair follicle placode formation PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within hemopoiesis PubMed 
    involved_in hindbrain development PubMed 
    involved_in hypothalamus development PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within layer formation in cerebral cortex PubMed 
    acts_upstream_of_or_within lens morphogenesis in camera-type eye PubMed 
    acts_upstream_of_or_within limb development PubMed 
    acts_upstream_of_or_within lung cell differentiation PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of lung epithelial cell differentiation PubMed 
    acts_upstream_of_or_within lung induction PubMed 
    acts_upstream_of_or_within lung-associated mesenchyme development PubMed 
    acts_upstream_of_or_within male genitalia development PubMed 
    acts_upstream_of mesenchymal cell proliferation PubMed 
    acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development PubMed 
    involved_in mesenchymal stem cell differentiation PubMed 
    involved_in mesenchymal stem cell differentiation  
    involved_in mesenchyme development PubMed 
    involved_in mesenchyme morphogenesis PubMed 
    acts_upstream_of_or_within metanephros morphogenesis PubMed 
    involved_in midbrain development PubMed 
    involved_in midbrain dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within morphogenesis of embryonic epithelium PubMed 
    acts_upstream_of myoblast proliferation PubMed 
    acts_upstream_of_or_within myoblast proliferation PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of angiogenesis PubMed 
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of cell differentiation PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of chondrocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of chondrocyte differentiation PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression  
    acts_upstream_of_or_within negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis PubMed 
    involved_in negative regulation of mitotic cell cycle, embryonic PubMed 
    involved_in negative regulation of neurogenesis PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of osteoclast differentiation PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of protein sumoylation  
    involved_in negative regulation of protein sumoylation  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within nephron tubule formation PubMed 
    acts_upstream_of_or_within neural plate development PubMed 
    acts_upstream_of neuroblast proliferation PubMed 
    involved_in neuron differentiation PubMed 
    acts_upstream_of_or_within neuron fate determination PubMed 
    acts_upstream_of_or_within neuron migration PubMed 
    involved_in neuron projection extension  
    involved_in neuron projection extension  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of oligodendrocyte differentiation PubMed 
    acts_upstream_of_or_within oocyte development PubMed 
    acts_upstream_of osteoblast differentiation PubMed 
    involved_in osteoblast differentiation  
    acts_upstream_of osteoclast differentiation PubMed 
    acts_upstream_of_or_within osteoclast differentiation PubMed 
    involved_in outflow tract morphogenesis PubMed 
    acts_upstream_of_or_within oviduct development PubMed 
    acts_upstream_of_or_within pancreas development PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of branching involved in lung morphogenesis PubMed 
    involved_in positive regulation of cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of determination of dorsal identity PubMed 
    acts_upstream_of_or_within positive regulation of endothelial cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development PubMed 
    acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process  
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation PubMed 
    involved_in positive regulation of molecular function PubMed 
    acts_upstream_of_or_within positive regulation of myoblast proliferation PubMed 
    involved_in positive regulation of neural precursor cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of neuroblast proliferation PubMed 
    involved_in positive regulation of neuroblast proliferation PubMed 
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of odontoblast differentiation PubMed 
    acts_upstream_of_or_within positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of skeletal muscle tissue development PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation PubMed 
    acts_upstream_of positive regulation of telomere maintenance via telomerase PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription elongation by RNA polymerase II PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within protein localization PubMed 
    involved_in protein localization to cell surface  
    involved_in protein localization to cell surface  
    involved_in protein polyubiquitination  
    involved_in protein polyubiquitination  
    acts_upstream_of_or_within proximal/distal pattern formation PubMed 
    acts_upstream_of_or_within regulation of T cell proliferation PubMed 
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    involved_in regulation of calcium ion import  
    involved_in regulation of calcium ion import  
    acts_upstream_of_or_within regulation of cell differentiation PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of centriole-centriole cohesion  
    involved_in regulation of centriole-centriole cohesion  
    involved_in regulation of centromeric sister chromatid cohesion PubMed 
    involved_in regulation of centromeric sister chromatid cohesion  
    acts_upstream_of_or_within regulation of epithelial cell differentiation PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of myelination PubMed 
    involved_in regulation of nephron tubule epithelial cell differentiation PubMed 
    involved_in regulation of neurogenesis PubMed 
    acts_upstream_of_or_within regulation of osteoblast differentiation PubMed 
    acts_upstream_of_or_within regulation of osteoclast differentiation PubMed 
    involved_in regulation of protein localization to cell surface  
    involved_in regulation of protein localization to cell surface  
    involved_in regulation of protein ubiquitination  
    involved_in regulation of protein ubiquitination  
    acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation PubMed 
    involved_in regulation of smooth muscle cell proliferation  
    involved_in regulation of smooth muscle cell proliferation  
    involved_in regulation of synapse assembly PubMed 
    involved_in regulation of synapse assembly PubMed 
    involved_in regulation of timing of anagen PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within renal inner medulla development PubMed 
    acts_upstream_of_or_within renal outer medulla development PubMed 
    acts_upstream_of_or_within renal vesicle formation PubMed 
    involved_in response to cytokine  
    involved_in response to estradiol  
    involved_in response to estradiol  
    involved_in response to estrogen  
    involved_in response to xenobiotic stimulus  
    acts_upstream_of_or_within skeletal system development PubMed 
    acts_upstream_of_or_within skin development PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    involved_in sympathetic ganglion development PubMed 
    acts_upstream_of_or_within synapse organization PubMed 
    involved_in synaptic vesicle clustering PubMed 
    involved_in synaptic vesicle clustering PubMed 
    acts_upstream_of_or_within synaptic vesicle transport PubMed 
    acts_upstream_of_or_within thymus development PubMed 
    acts_upstream_of_or_within tissue homeostasis PubMed 
    acts_upstream_of_or_within trachea formation PubMed 
    acts_upstream_of_or_within trachea morphogenesis PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within vasculature development PubMed 
    acts_upstream_of_or_within vasculogenesis PubMed 
    involved_in ventricular compact myocardium morphogenesis PubMed 
    Items 1 - 25 of 273
    Items 1 - 20 of 86
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    part_of Scrib-APC-beta-catenin complex PubMed 
    part_of Wnt signalosome PubMed 
    located_in Z disc PubMed 
    is_active_in adherens junction  
    located_in adherens junction PubMed 
    located_in adherens junction  
    located_in apical junction complex PubMed 
    located_in apical part of cell PubMed 
    located_in apical plasma membrane  
    located_in apicolateral plasma membrane PubMed 
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    part_of beta-catenin destruction complex PubMed 
    part_of beta-catenin destruction complex  
    part_of beta-catenin destruction complex  
    part_of beta-catenin-ICAT complex PubMed 
    part_of beta-catenin-TCF complex PubMed 
    part_of beta-catenin-TCF complex  
    part_of beta-catenin-TCF7L2 complex  
    part_of beta-catenin-TCF7L2 complex  
    located_in bicellular tight junction PubMed 
    part_of catenin complex  
    part_of catenin complex PubMed 
    part_of catenin complex PubMed 
    part_of catenin complex  
    part_of catenin complex  
    located_in cell cortex  
    located_in cell cortex  
    located_in cell junction  
    located_in cell junction  
    located_in cell periphery  
    located_in cell periphery  
    located_in cell projection membrane PubMed 
    located_in cell-cell junction PubMed 
    located_in cell-cell junction PubMed 
    located_in centrosome PubMed 
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in dendritic shaft  
    located_in euchromatin PubMed 
    located_in euchromatin  
    located_in fascia adherens PubMed 
    part_of flotillin complex PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in intercalated disc PubMed 
    located_in intercalated disc  
    located_in lamellipodium PubMed 
    located_in lateral plasma membrane PubMed 
    located_in lateral plasma membrane  
    located_in membrane PubMed 
    located_in membrane  
    located_in microvillus membrane PubMed 
    located_in nuclear membrane  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    is_active_in nucleus PubMed 
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density, intracellular component PubMed 
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic active zone cytoplasmic component PubMed 
    is_active_in presynaptic membrane PubMed 
    part_of protein-DNA complex  
    part_of protein-DNA complex  
    part_of protein-containing complex PubMed 
    located_in spindle pole  
    located_in synapse PubMed 
    located_in tight junction  
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  
    Items 1 - 20 of 86

    General protein information

    Preferred Names
    catenin beta-1
    Names
    beta-catenin
    catenin (cadherin associated protein), beta 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165902.2NP_001159374.1  catenin beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001159374.1

      Status: VALIDATED

      Source sequence(s)
      AC145731
      Consensus CDS
      CCDS23630.1
      UniProtKB/Swiss-Prot
      Q02248, Q922W1, Q9D335
      UniProtKB/TrEMBL
      Q3UZT7
      Related
      ENSMUSP00000136294.2, ENSMUST00000178812.9
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    2. NM_001431671.1NP_001418600.1  catenin beta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145731
      UniProtKB/Swiss-Prot
      Q02248, Q922W1, Q9D335
      UniProtKB/TrEMBL
      Q3UZT7
    3. NM_001431672.1NP_001418601.1  catenin beta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145731
      UniProtKB/Swiss-Prot
      Q02248, Q922W1, Q9D335
      UniProtKB/TrEMBL
      Q3UZT7
    4. NM_001431673.1NP_001418602.1  catenin beta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC145731
      UniProtKB/Swiss-Prot
      Q02248, Q922W1, Q9D335
      UniProtKB/TrEMBL
      Q3UZT7
    5. NM_001431674.1NP_001418603.1  catenin beta-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145731
      UniProtKB/TrEMBL
      Q3UZT7
    6. NM_001431675.1NP_001418604.1  catenin beta-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145731
      UniProtKB/TrEMBL
      Q3UZT7
    7. NM_007614.4NP_031640.1  catenin beta-1 isoform 1

      See identical proteins and their annotated locations for NP_031640.1

      Status: VALIDATED

      Source sequence(s)
      AC145731
      Consensus CDS
      CCDS23630.1
      UniProtKB/Swiss-Prot
      Q02248, Q922W1, Q9D335
      UniProtKB/TrEMBL
      Q3UZT7
      Related
      ENSMUSP00000007130.9, ENSMUST00000007130.15
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      120762466..120789573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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