Parp14 poly (ADP-ribose) polymerase family, member 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp14provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 14provided by MGI
Primary source: MGI:MGI:1919489
See related: Ensembl:ENSMUSG00000034422 AllianceGenome:MGI:1919489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD8; CoaSt6; mKIAA1268; 1600029O10Rik
Summary: Predicted to enable several functions, including NAD+ binding activity; NAD+-protein poly-ADP-ribosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of type II interferon-mediated signaling pathway and positive regulation of interleukin-4-mediated signaling pathway. Located in cytoplasm. Is expressed in hemolymphoid system; intestine; and urogenital sinus. Orthologous to human PARP14 (poly(ADP-ribose) polymerase family member 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 6.0), bladder adult (RPKM 4.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 25.43 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (35652262..35691904, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (35831892..35871518, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis.
Title: Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis.
PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.
Title: PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.
PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
Title: PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
murine Artd8 macrodomain constructs can serve as a tool to evaluate intracellular ARTD10 auto-modification levels using the described methods, while the human ARTD8 macrodomains are less suited because of ADPr-independent binding to ARTD10. Protocols for co-immunoprecipitation and co-localization experiments are described in detail.
Title: Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8.
the data hint at a role of PARP14 in the control of antimicrobial responses and specifically in nuclear activities of a subgroup of Interferon-stimulated gene-encoded proteins.
Title: PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins.
PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4; PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells
Title: PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
PARP14 has an intrinsic role in Th2 cytokine control to limit the severity of allergic skin disease.
Title: Poly-ADP ribose polymerase-14 limits severity of allergic skin disease.
these studies demonstrate that PARP-14 regulates multiple cytokine responses during inflammatory immunity.
Title: Poly-ADP-ribosyl polymerase-14 promotes T helper 17 and follicular T helper development.
study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14.
Title: PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression.
PARP-14 is an important factor for T helper cell differentiation and it binds to specific DNA sequences to mediate its function.
Title: PARP-14 binds specific DNA sequences to promote Th2 cell gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP14

Names: ADP-ribosyltransferase diphtheria toxin-like 8; PARP-14; collaborator of STAT6; poly [ADP-ribose] polymerase 14

NP_001034619.2

EC 2.4.2.30

XP_006522455.1

EC 2.4.2.30

XP_006522457.2

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039530.3 → NP_001034619.2 protein mono-ADP-ribosyltransferase PARP14

See identical proteins and their annotated locations for NP_001034619.2

Status: VALIDATED

Source sequence(s)

AC129574

Consensus CDS

CCDS28143.1

UniProtKB/Swiss-Prot

E9QP48, Q2EMV9, Q571C6, Q8BN35, Q8VDT6

UniProtKB/TrEMBL

B2RSI3

Related

ENSMUSP00000037657.9, ENSMUST00000042665.9

Conserved Domains (8) summary

COG2110
Location:812 → 991

YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]

cd01439
Location:1695 → 1815

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:1025 → 1167

Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...

cd02907
Location:812 → 987

Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

cd12300
Location:6 → 87

RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cd12543
Location:226 → 300

RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

pfam00644
Location:1644 → 1817

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl00019
Location:1240 → 1365

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

35652262..35691904 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522392.5 → XP_006522455.1 protein mono-ADP-ribosyltransferase PARP14 isoform X1

UniProtKB/TrEMBL

B2RSI3

Conserved Domains (5) summary

smart00506
Location:1240 → 1358

A1pp; Appr-1"-p processing enzyme

cd01439
Location:1724 → 1844

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd12300
Location:6 → 87

RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cd12543
Location:226 → 300

RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cl00019
Location:812 → 986

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
XM_006522394.5 → XP_006522457.2 protein mono-ADP-ribosyltransferase PARP14 isoform X2

UniProtKB/TrEMBL

B2RSI3

Conserved Domains (5) summary

smart00506
Location:1245 → 1363

A1pp; Appr-1"-p processing enzyme

cd01439
Location:1700 → 1820

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd12300
Location:6 → 92

RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cd12543
Location:231 → 305

RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cl00019
Location:817 → 991

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...