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    Zfyve28 zinc finger, FYVE domain containing 28 [ Mus musculus (house mouse) ]

    Gene ID: 231125, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfyve28provided by MGI
    Official Full Name
    zinc finger, FYVE domain containing 28provided by MGI
    Primary source
    MGI:MGI:2684992
    See related
    Ensembl:ENSMUSG00000037224 AllianceGenome:MGI:2684992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm146; mKIAA1643; 9630058O20Rik
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 4.9), cortex adult (RPKM 3.0) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zfyve28 in Genome Data Viewer
    Location:
    5 B2; 5 17.85 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34352237..34445796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34194893..34288368, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA polymerase N Neighboring gene STARR-positive B cell enhancer ABC_E1299 Neighboring gene STARR-seq mESC enhancer starr_12836 Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34530746-34530855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34537815-34537924 Neighboring gene Max dimerization protein 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34575558-34575759 Neighboring gene cilia and flagella associated protein 99 Neighboring gene RIKEN cDNA A830049F12 gene Neighboring gene predicted gene 5553 Neighboring gene STARR-positive B cell enhancer ABC_E668 Neighboring gene ring finger protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • AC104889.1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    lateral signaling target protein 2 homolog
    Names
    zinc finger FYVE domain-containing protein 28

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015039.1NP_001015039.1  lateral signaling target protein 2 homolog

      See identical proteins and their annotated locations for NP_001015039.1

      Status: PROVISIONAL

      Source sequence(s)
      AK129414
      Consensus CDS
      CCDS39068.1
      UniProtKB/Swiss-Prot
      B2RSX8, Q6ZPK7
      Related
      ENSMUSP00000092464.4, ENSMUST00000094868.10
      Conserved Domains (1) summary
      cd15731
      Location:828892
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      34352237..34445796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503886.2XP_006503949.1  lateral signaling target protein 2 homolog isoform X2

      Conserved Domains (1) summary
      cd15731
      Location:781845
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
    2. XM_036165019.1XP_036020912.1  lateral signaling target protein 2 homolog isoform X1

      Conserved Domains (1) summary
      cd15731
      Location:724788
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
    3. XM_011240724.1XP_011239026.1  lateral signaling target protein 2 homolog isoform X4

      Conserved Domains (1) summary
      cd15731
      Location:323387
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
    4. XM_006503887.1XP_006503950.1  lateral signaling target protein 2 homolog isoform X3

      Conserved Domains (1) summary
      cd15731
      Location:614678
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
    5. XM_017320831.3XP_017176320.1  lateral signaling target protein 2 homolog isoform X5

      Conserved Domains (1) summary
      cd15731
      Location:494558
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
    6. XM_011240725.2XP_011239027.1  lateral signaling target protein 2 homolog isoform X6

    7. XM_011240726.4XP_011239028.2  lateral signaling target protein 2 homolog isoform X8

    8. XM_011240727.4XP_011239029.2  lateral signaling target protein 2 homolog isoform X9

    9. XM_011240728.2XP_011239030.1  lateral signaling target protein 2 homolog isoform X7

      See identical proteins and their annotated locations for XP_011239030.1

    RNA

    1. XR_003955626.1 RNA Sequence