Itpkb inositol 1,4,5-trisphosphate 3-kinase B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itpkbprovided by MGI
Official Full Name: inositol 1,4,5-trisphosphate 3-kinase Bprovided by MGI
Primary source: MGI:MGI:109235
See related: Ensembl:ENSMUSG00000038855 AllianceGenome:MGI:109235
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110033J02Rik; E130307H12Rik
Summary: Enables inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Located in cytosol; membrane; and nucleus. Is expressed in alimentary system; facial bone primordium; liver; nervous system; and urinary system. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 21.8), thymus adult (RPKM 19.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 84.27 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (180156655..180252367)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (180330390..180424802)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells.
Title: Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells.
The Parkinson's disease-associated gene ITPKB protects against alpha-synuclein aggregation by regulating ER-to-mitochondria calcium release.
Title: The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb restricts pre-T cell receptor induced metabolic activation to enforce coincidence-detection of pre-T cell receptor expression and Notch-engagement.
Title: Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.
These data identify Itpkb as an essential mediator of T cell activation and suggest Itpkb inhibition as a novel approach to treat autoimmune disease.
Title: Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
Itpkb controls hematopoietic stem cell homeostasis and prevent death from severe anemia in mice.
Title: IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.
Itpkb controls survival, proliferation and cytokine production in mouse peripheral T cells.
Title: Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells.
controls survival and prevents anergy in B cells
Title: Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells.
These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]
Title: The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts.
B cells from Itpkb(-/-) Ig hen egg lysozyme mice possess an anergic phenotype, hypoproliferate in response to cognate Ag, and yet they exhibit enhanced Ag-induced calcium signaling
Title: Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction.
InsP3KB is also a physiological modulator of myelopoiesis.
Title: Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140655 (e-PCR)
- UniSTS:222724

Itpkb (e-PCR), detects polymorphism
- UniSTS:143634

Itpkb (e-PCR), detects polymorphism
- UniSTS:546834

D1Mit426 (e-PCR), detects polymorphism
- UniSTS:128792

UniSTS:234290 (e-PCR)
- UniSTS:234290

RH94655 (e-PCR)
- UniSTS:119902

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inositol hexakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5-trisphosphate 3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol-1,4,5-trisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within common myeloid progenitor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol trisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inositol-trisphosphate 3-kinase B

NP_001074644.1

EC 2.7.1.127

NP_001405214.1

EC 2.7.1.127

NP_001405215.1

EC 2.7.1.127

XP_006496965.1

EC 2.7.1.127

XP_030110829.1

EC 2.7.1.127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081175.2 → NP_001074644.1 inositol-trisphosphate 3-kinase B isoform a

See identical proteins and their annotated locations for NP_001074644.1

Status: VALIDATED

Source sequence(s)

AC121838

Consensus CDS

CCDS35808.1

UniProtKB/TrEMBL

B2RXC2

Related

ENSMUSP00000069851.7, ENSMUST00000070181.7

Conserved Domains (2) summary

PHA03307
Location:24 → 317

PHA03307; transcriptional regulator ICP4; Provisional

pfam03770
Location:722 → 933

IPK; Inositol polyphosphate kinase
NM_001418285.1 → NP_001405214.1 inositol-trisphosphate 3-kinase B isoform a

Status: VALIDATED

Source sequence(s)

AC121838

UniProtKB/TrEMBL

B2RXC2
NM_001418286.1 → NP_001405215.1 inositol-trisphosphate 3-kinase B isoform b

Status: VALIDATED

Source sequence(s)

AC121838

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

180156655..180252367

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496902.5 → XP_006496965.1 inositol-trisphosphate 3-kinase B isoform X2

UniProtKB/TrEMBL

Q8BKB2
XM_030254969.2 → XP_030110829.1 inositol-trisphosphate 3-kinase B isoform X1

UniProtKB/TrEMBL

B2RXC2

Conserved Domains (2) summary

PHA03307
Location:24 → 317

PHA03307; transcriptional regulator ICP4; Provisional

pfam03770
Location:722 → 933

IPK; Inositol polyphosphate kinase