Kctd21 potassium channel tetramerisation domain containing 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd21provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 21provided by MGI
Primary source: MGI:MGI:3643121
See related: Ensembl:ENSMUSG00000044952 AllianceGenome:MGI:3643121
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG622320
Summary: Predicted to enable cullin family protein binding activity; histone deacetylase binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Orthologous to human KCTD21 (potassium channel tetramerization domain containing 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 5.1), subcutaneous fat pad adult (RPKM 4.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.47 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (96981524..96999420)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (97332308..97350216)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD21

Names: K+ channel tetramerisation/BTB/POZ/BTB domain profile containing protein; KCASH2 protein; potassium channel tetramerization domain-containing protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039039.4 → NP_001034128.2 BTB/POZ domain-containing protein KCTD21

See identical proteins and their annotated locations for NP_001034128.2

Status: VALIDATED

Source sequence(s)

AC155933

Consensus CDS

CCDS21456.1

UniProtKB/Swiss-Prot

Q3URF8

UniProtKB/TrEMBL

B2RTJ2

Related

ENSMUSP00000051316.6, ENSMUST00000054107.6

Conserved Domains (1) summary

cd18395
Location:3 → 100

BTB_POZ_KCTD21; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21)
NM_001421531.1 → NP_001408460.1 BTB/POZ domain-containing protein KCTD21

Status: VALIDATED

Source sequence(s)

AC155933

UniProtKB/Swiss-Prot

Q3URF8

UniProtKB/TrEMBL

B2RTJ2