Ndrg4 N-myc downstream regulated gene 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndrg4provided by MGI
Official Full Name: N-myc downstream regulated gene 4provided by MGI
Primary source: MGI:MGI:2384590
See related: Ensembl:ENSMUSG00000036564 AllianceGenome:MGI:2384590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ndr4; SMAP-8; Ndr1-rs; D8Bwg1337e
Summary: Involved in several processes, including regulation of endocytic recycling; vesicle docking; and visual learning. Located in cell projection membrane and cytoplasm. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and retina. Orthologous to human NDRG4 (NDRG family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 385.8), cerebellum adult (RPKM 322.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D1; 8 47.12 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (96403602..96441584)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (95676974..95714956)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein
Title: NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.
NDRG4 might play an important role during early pregnancy.
Title: Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice.
up-regulation of NDRG4 aggravates myocardial ischemia/reperfusion injury by inhibiting activation of the RISK pathway
Title: N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway.
Availability of the conditional allele for Ndrg4 should facilitate further detailed analyses of the potential roles of Ndrg4 in gut development, nervous system and immune system.
Title: Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice.
Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
Title: Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
NDRG4 contributes to the maintenance of intracerebral BDNF levels within the normal range
Title: NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.
NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells
Title: NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain.
Title: Differential expression patterns of NDRG family proteins in the central nervous system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndrg4 (e-PCR), detects polymorphism
- UniSTS:498270

Ndr1-rs (e-PCR), detects polymorphism
- UniSTS:143998

RH125143 (e-PCR)
- UniSTS:161965

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein NDRG4

Names: N-myc downstream regulated 1, related sequence; N-myc downstream-regulated gene 4 protein; protein Ndr4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195006.2 → NP_001181935.1 protein NDRG4 isoform A

See identical proteins and their annotated locations for NP_001181935.1

Status: VALIDATED

Source sequence(s)

AC113951

Consensus CDS

CCDS57634.1

UniProtKB/Swiss-Prot

Q6ZPW3, Q8BTG7, Q923D7

Related

ENSMUSP00000072883.8, ENSMUST00000073139.14

Conserved Domains (1) summary

pfam03096
Location:8 → 290

Ndr; Ndr family
NM_001372421.1 → NP_001359350.1 protein NDRG4 isoform C

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:60 → 342

Ndr; Ndr family
NM_001372423.1 → NP_001359352.1 protein NDRG4 isoform C

Status: VALIDATED

Source sequence(s)

AC113951

Consensus CDS

CCDS90441.1

Related

ENSMUSP00000036226.8, ENSMUST00000041318.14

Conserved Domains (1) summary

pfam03096
Location:60 → 342

Ndr; Ndr family
NM_001372425.1 → NP_001359354.1 protein NDRG4 isoform D

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:60 → 342

Ndr; Ndr family
NM_001372426.1 → NP_001359355.1 protein NDRG4 isoform D

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:60 → 342

Ndr; Ndr family
NM_001372427.1 → NP_001359356.1 protein NDRG4 isoform E

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:40 → 322

Ndr; Ndr family
NM_001372428.1 → NP_001359357.1 protein NDRG4 isoform E

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:40 → 322

Ndr; Ndr family
NM_001372429.1 → NP_001359358.1 protein NDRG4 isoform F

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:40 → 322

Ndr; Ndr family
NM_001372430.1 → NP_001359359.1 protein NDRG4 isoform G

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:40 → 306

Ndr; Ndr family
NM_001372431.1 → NP_001359360.1 protein NDRG4 isoform H

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:8 → 289

Ndr; Ndr family
NM_001372432.1 → NP_001359361.1 protein NDRG4 isoform I

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:8 → 289

Ndr; Ndr family
NM_001372433.1 → NP_001359362.1 protein NDRG4 isoform J

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:8 → 274

Ndr; Ndr family
NM_001372434.1 → NP_001359363.1 protein NDRG4 isoform K

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:8 → 269

Ndr; Ndr family
NM_001372435.1 → NP_001359364.1 protein NDRG4 isoform L

Status: VALIDATED

Source sequence(s)

AC113951

Conserved Domains (1) summary

pfam03096
Location:8 → 261

Ndr; Ndr family
NM_145602.4 → NP_663577.1 protein NDRG4 isoform B

See identical proteins and their annotated locations for NP_663577.1

Status: VALIDATED

Source sequence(s)

AC113951

Consensus CDS

CCDS22565.1

UniProtKB/Swiss-Prot

Q8BTG7

Related

ENSMUSP00000079495.8, ENSMUST00000080666.8

Conserved Domains (1) summary

pfam03096
Location:8 → 290

Ndr; Ndr family