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    Umodl1 uromodulin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 52020, updated on 27-Nov-2024

    Summary

    Official Symbol
    Umodl1provided by MGI
    Official Full Name
    uromodulin-like 1provided by MGI
    Primary source
    MGI:MGI:1929785
    See related
    Ensembl:ENSMUSG00000054134 AllianceGenome:MGI:1929785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D17Ertd488e
    Summary
    Predicted to enable calcium ion binding activity and peptidase inhibitor activity. Acts upstream of or within several processes, including cellular response to gonadotropin-releasing hormone; regulation of granulosa cell apoptotic process; and regulation of ovarian follicle development. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human UMODL1 (uromodulin like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 3.0), ovary adult (RPKM 0.9) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Umodl1 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.8 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31173614..31229684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (30954648..31010710)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene glucagon-like peptide 1 receptor Neighboring gene predicted gene, 41562 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31148766-31148949 Neighboring gene STARR-seq mESC enhancer starr_42318 Neighboring gene STARR-positive B cell enhancer ABC_E5588 Neighboring gene STARR-seq mESC enhancer starr_42319 Neighboring gene STARR-positive B cell enhancer ABC_E7512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31214721-31214922 Neighboring gene ATP binding cassette subfamily G member 1 Neighboring gene trefoil factor 3, intestinal

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    uromodulin-like 1
    Names
    olfactorin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177465.4NP_803416.2  uromodulin-like 1 precursor

      See identical proteins and their annotated locations for NP_803416.2

      Status: VALIDATED

      Source sequence(s)
      AY771617, BC051427
      Consensus CDS
      CCDS37543.1
      UniProtKB/Swiss-Prot
      Q5DID3
      Related
      ENSMUSP00000110202.2, ENSMUST00000114555.3
      Conserved Domains (8) summary
      smart00179
      Location:502529
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:10251265
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:930973
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00041
      Location:737814
      fn3; Fibronectin type III domain
      pfam00095
      Location:120158
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam00100
      Location:11581265
      Zona_pellucida; Zona pellucida-like domain
      pfam01390
      Location:391467
      SEA; SEA domain
      cl02507
      Location:829895
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31173614..31229684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524614.3XP_006524677.1  uromodulin-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006524677.1

      UniProtKB/Swiss-Prot
      Q5DID1, Q5DID2, Q5DID3
      Related
      ENSMUSP00000157726.2, ENSMUST00000237889.2
      Conserved Domains (7) summary
      smart00179
      Location:502529
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:901944
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00041
      Location:708784
      fn3; Fibronectin type III domain
      pfam00095
      Location:118158
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam00100
      Location:9961236
      Zona_pellucida; Zona pellucida-like domain
      cl02507
      Location:800866
      SEA; SEA domain
      cl21522
      Location:306370
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...