Clca4a chloride channel accessory 4A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clca4aprovided by MGI
Official Full Name: chloride channel accessory 4Aprovided by MGI
Primary source: MGI:MGI:2139744
See related: Ensembl:ENSMUSG00000068547 AllianceGenome:MGI:2139744
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clca4; Clca6; 9130020L07Rik
Summary: Enables chloride channel activity and ligand-gated monoatomic ion channel activity. Acts upstream of or within chloride transport. Located in plasma membrane. Is expressed in skeletal muscle; testis; and thymus. Orthologous to human CLCA4 (chloride channel accessory 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 99.6), small intestine adult (RPKM 44.9) and 2 other tissues See more
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Genomic context

Location:: 3 H2; 3 69.22 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (144658247..144680806, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (144952486..144975045, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cleavage of the mCLCA6 E157Q variant protein is zinc-dependent and sensitive to metalloprotease inhibitors, suggesting secondary cleavage by a metalloprotease.
Title: Impaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage at the plasma membrane instead of the endoplasmic reticulum.
mCLCA6 is colocalized with CFTR at the surface of colonic crypt cells
Title: Murine mCLCA6 is an integral apical membrane protein of non-goblet cell enterocytes and co-localizes with the cystic fibrosis transmembrane conductance regulator.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

Clca4 (e-PCR), detects polymorphism
- UniSTS:547970

AI504701 (e-PCR)
- UniSTS:159197

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly calcium-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chloride transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium-activated chloride channel regulator 4A

Names: calcium activated chloride channel; calcium-activated chloride channel regulator 4; calcium-activated chloride channel regulator 6; chloride channel calcium activated 4A; chloride channel calcium activated 6; mClca6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207208.3 → NP_997091.3 calcium-activated chloride channel regulator 4A precursor

See identical proteins and their annotated locations for NP_997091.3

Status: VALIDATED

Source sequence(s)

AK033591

Consensus CDS

CCDS38661.1

UniProtKB/TrEMBL

A0A5F8MQB6, G3X8Z1

Related

ENSMUSP00000159165.2, ENSMUST00000238960.2

Conserved Domains (2) summary

cd00198
Location:307 → 459

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam08434
Location:26 → 899

CLCA; Calcium-activated chloride channel